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0.4% ; had a local adverse effect.4 However, subcutaneous injections can cause abscesses and granulomas.1 5 6 Muscle is probably spared the harmful effects of substances injected into it because of its abundant blood supply.5 Adipose tissue, having much poorer drainage channels, retains injected material for much longer and is therefore also more susceptible to its adverse effects.5 In the case of vaccines in which the antigen is adsorbed to an aluminium salt adjuvant--such as those for hepatitis A, hepatitis B, and diphtheria, tetanus, and pertussis vaccines--the intramuscular route is strongly preferred because superficial administration leads to an increased incidence of local reactions such as irritation, inflammation, granuloma formation, and necrosis.2 7 8 The injection technique and needle size both determine how deep a substance is injected. Injection technique involves stretching the skin flat before inserting the needle or pinching a fold of skin before injection, which may necessitate the use of longer needles. To make sure the needle reaches the muscle and that vaccine does not seep into subcutaneous tissue the decision on the size of the needle and injection site should be made individually for each person. It should also be based on the person's age, the volume of material to be administered, and the size of the muscle.9 In a recent study, the thickness of the fat pad above the deltoid muscle of the upper arm was measured in 220 adults healthcare workers presenting for hepatitis B immunisation ; using high frequency ultrasonography.1 A wide variation exists in thickness of the deltoid fat pad, with women having significantly more subcutaneous fat than men. A standard 5 8 inch 16mm ; needle would not have achieved sufficient penetration for true deltoid intramuscular injection in. Information shipping information terms & conditions about us contact us faq home : : allergies : : cetirizine zyrtec ; centirizine-hexal 10mg, 60tabs search featured alprazolam xanax ; zopax 1mg, 100tabs $6 00 manufacturers manufacturer info hexal homepage other products shopping cart your cart is empty.
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Synopsis According to a report in the December issue of Obstetrics and Gynecology, most women who try to discontinue HRT following publication of the Women's Health Initiative WHI ; study, are successful however, about one quarter resume therapy because of troublesome withdrawal symptoms. Six to eight months after the WHI results were published, researchers surveyed 670 women aged 50 to 69 years ; who had used HRT regularly for at least 1 year. According to their results, 93% of the subjects had some awareness of the new findings, but only 23% were correctly informed. More than half of the women n 377 ; tried to stop using HRT. Thirty percent reported "troublesome symptoms, " such as vasomotor symptoms, mood problems, fatigue and vaginal dryness starting a median of 1 week after stopping HRT. During a median of 5.7 months after stopping, 97 26% ; resumed taking HRT. However, the researchers point out, approximately 20% of women who remained off therapy also experienced withdrawal symptoms. Women with troublesome withdrawal symptoms were almost nine times as likely to resume HRT use. Having a hysterectomy, receiving HRT from a non-gynaecologist, and self-perceived higher than average risk of fracture were also associated with increased risk of failure to discontinue and achromycin.
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