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1. 1999 Guide to the Management of Hypertension for Doctors. National Heart Foundation of Australia 1999: Canberra. 1999 WHO--ISH Guidelines for the Management of Hypertension. J Hypertens 1999; 17: 151 SHEP Cooperative Research Group. JAMA 1991; 265: 325564. Staessen JA et al. Lancet 1997; 350: 757 MRC trial. BMJ 1985; 219: 97104. MRC trial. BMJ 1992; 304: 405412. Ames RP. J Cardiology 1996; 77 6 ; : 12B16B. 11. 12. Angiotensin II receptor blockers: their role in hypertension and congestive heart failure. University of British Columbia: Therapeutic Initiative; 1999. Drug Utilisation Sub-committee. Personal communication, secretary. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. JAMA. 2000; 283: 19671975. Pahor M et al. Lancet 2000; 356: 194954. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet 2000; 356: 195564.
Tourette syndrome and its treatment ADHD is probably the most commonly encountered in TS, as evidenced by a vast literature on the subject Towbin and Riddle, 1993; Freeman, 1997 ; . Although early studies found ADHD in as few as 13% of TS patients Mak et al., 1982 ; , it is now evident that ADHD occurs in a substantial proportion of TS patients, ranging from 21 to 90% of clinic populations Robertson and Eapen, 1992 ; , clearly far in excess of the 2 15% Towbin and Riddle, 1993 ; or 419% Taylor et al., 1998 ; in the general population. Two epidemiological studies have, however, also examined ADHD in TS. Apter and colleagues examined all those recruited into the Israeli Defence Force during 1 year and reported the rate of ADHD in people with TS to be 8.3% compared with a population point prevalence of 3.9% in individuals without TS Apter et al., 1993 ; . Recently, Mason and colleagues undertook a school epidemiological study examining TS and tics. Of the 30 out of 167 18% ; tic possibles, there was no increase in ADHD in tic possibles compared with the other children, as rated by the short Connors scale; there was also no increase in hyperactivity as assessed by both the General Health and Behaviour Questionnaire, and Strength and Difficulty Questionnaire of Goodman 1994, 1997 ; . Four out of five 80% ; of the identified TS individuals definite and probable ; were, however, reported as hyperactive by their teachers, parents or both; one satisfied DSM-IV criteria for ADHD Mason et al., 1998 ; . It has also been pointed out that it is the symptoms of ADHD which often contribute to the behavioural disturbances, poor school performance and impaired executive functioning testing in children with TS Singer et al., 1995a ; . Attentional problems and difficulties with hyperactivity and impulse control frequently precede the emergence of the actual tics Jagger et al., 1982; Singer et al., 1995a ; . In fact, for the DSM-IV diagnosis to be made, symptoms of ADHD must be present in two or more settings before the age of 7 years; the TS tic symptoms, however, often begin later Robertson, 1989, 1994 ; . Only one study to date has examined the phenomenology of `pure' primary ; ADHD and compared it with that of TS plus ADHD Spencer et al., 1998 ; . It was demonstrated that in TS there were increased rates of both OCD and ADHD. In contrast to the comorbidity with OCD, it was found that the other comorbidities such as disruptive behaviours, mood disorder, anxiety disorder ; were indistinguishable in the comparison between children with TS plus ADHD and children with ADHD alone. This suggests that some psychopathology e.g. mood and anxiety ; could be secondary to the comorbidity with ADHD, rather than the TS per se. In addition it was shown that children with TS plus ADHD had lower psychosocial functioning than children with ADHD alone Spencer et al., 1998 ; . A more recent paper Spencer et al., 1999 ; compared 128 male children and adolescents with 110 controls, at baseline and 4 years later; when compared with controls, ADHD youngsters had more tic disorders initially and more new onsets at follow-up. Of, for instance, osteopenia.
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Ithin Confederation. the telephone was ringing at 8: 15 the morning after. '1 picked it up and someone said, "I feel totally disenfranchised today." ' says administration officer Nancy Sanford. 'Every five minutes since, there has been another call. A quarter of the callers are looking for a separatist party, which we aren't. The rest are saying they feel totally sick and they want to voice their frustration to someone.' " l10m serious is this possibility of' Alberta separatism taken'? Of course. short of shipping oil by pipeline to Montana, land-locked Alherta has the Pacific coastline - and an equally strong separatist pull Again. from Maclran's, "BC IN POLITICAL ISOLATION. And it is Perrault Liberal senator from BC who is reminding Trudeau of events such as last w e k radio survey that showed six out of every 10 callers in favor of separation from the rest of . ~ 'But usually it's just the dissidents who call these shows, ' , . a. he philosophizes." The quote comes from the lead article in Maclean's. along with a cartoon showing Trudeau facing a battery of microphones, with an array of knives. arrows, tomahawks and darts protruding from his backside " . and 1 reminded that while we face the threat of separ&sm in Quebec, we must not turn our backs on the dienation of the West ." Yes, the threat of Western separatism is taken seriously. Even thoilgh the other two Western Provinces elected only two L.ibemls total from urban Manitoba ; giving an Alberta - British Columbia "Rocky Mountain Republic" a nice buffer zone, the hattle will be fought economically, not on the battlefield. The fact that Alberta is rich and economically free. and the rest of Canada is suffering under austerity budgets and heavy government regulation and taxation is the key. And it's also the problem because there is no firm ideological leadership in the West. Lougheed is simply a conservative who is following the political dynamics of the situation which lwds him to the coming confrontation with Ottawa the federal capital ; over oil controls. But he's not fighting for Alberta non-regulation of' pertroleurn vs federal regulation. rather they're arguing how the plunder should be divided. This could kill any principled rally against the central state. And. finally, the link between Quebec and Western separatists must he established. Again, Lougheed is not the medium, a symbol of a relatively sophisticated, to be sure ; anti-frog mentality, and not likely to win Levesque's support. The old Social Credit Party, strong precisely in Alberta. Quebec and still the provincial government in British Columbia ; would have been the perfect.
By our pharma correspondent pharma news headlines cancer news cardiac news us fda news pharma industry news diseases - alzheimer's, parkisonson's and obesity contraception and abortion news latest updates anti fungal terbinafine launched in europe: actavis hiv entry blocking drug data encouraging: progenics allegra generic to be launched in us long-acting pain drug data positive: pain therapeutics new kidney cancer drug seeks eu nod inhaled insulin may get us fda clearance a vaccine against fungus is on way enzyme stops progression of hiv in survivors, confirms study aclasta found faster-acting in paget's disease treatment beta blocker can start therapy in heart failure: merck halobetasol generic launched in us anemia drug darbepoetin's late-stage studies begin: amgen cholesterol generic gets marketing nod in us: par aricept for severe alzheimer's disease too: eisai bone regeneration trials begin in us: mesoblast new dye to detect early alzheimer's breast forming gene discovered thyroid drug to be supplied by ivax in us rituxan, cancer drug can treat rheumatoid arthritis yasminelle, low-dose oral contraceptive approved in the netherlands fluarix, anti-flu shot by glaxo approved increlex, drug to treat `abnormally short' kids approved in us anti-hiv drugs prices cut: gilead us fda approves takeda's drug combo for type 2 diabetes novartis' drug for breast cancer recurrence to be given priority review in us us puts off decision on contraceptive pill again shire's adhd drug adderall back on list in canada who calls for emergency action to halt tb in africa some of the vioxx suits may be settled: merck nasdaq delists able on bankruptcy filing hospira ships ceftriaxone generics to us renovis stops sciatica drug studies merck sets up generic arm genpharm in us morning after pills still not within easy reach in us new cancer combo therapy results positive: oxigene aceon approved for heart disease treatment in us cell therapeutics to seek approval for lung cancer therapy in us and europe anti-depressant seroxat defended by gsk against new findings vioxx verdict: merck's defeat to trigger thousands of lawsuits from us, uk aspirin stops colon cancer, but may trigger bleeding new blood test method approved in us skin disease drug turns into anti-tumor therapy for cancer step-by-step instructions for dealing with asthma attacks potential alzheimer's disease drugs under investigation new molecule may help obese lose weight paxil paroxetine ; may heighten suicide risks, finds study breast cancer chances higher due to fried chips safety alert on gambro dasco's prisma renal system merck responsible for vioxx death: jury heart disease deaths more among new yorkers pfizer to offer drugs risk benefit summary to consumers merck lied to public on vioxx: lawyer tells jurors novartis acquires rights of kidney dialysis drug from sebo j& j's concerta approved treatment of adhd in teenagers in canada us fda stalls roche' accutane use in pregnancy novo nordisk, eli lilly remove insulin products from australia british drug supply chain safety questioned after another fake lipitor find wyeth starts support programme for effexor patients p& g's atconel with calcium approved for osteoporosis pozen gets patent on pain management product genmab studies new drug for rheumatoid arthritis painkillers may increase blood pressure: study nektar buys out aerogen for m predix records positive data on anxiety drug insmed files against increlex approval hepatitis a vaccine for kids approved in us psoriasis drug data positive: cytochroma novo nordisk's 24-hour acting insulin levemir gets us fda okay us fda approves teva's generic for osteoporosis home intl and adapalene.
Promotion can have two effects on demand: it may shift the demand curve outwards as doctors prescribe more of the advertised drug and or it may rotate the demand curve as demand becomes less or more price-elastic than before. In general, if product promotion lowers the price sensitivity, this will inhibit price competition and will lead to higher prices, thus harming social welfare. An outward shift of the demand curve for a drug could be socially desirable if this drug truly improves health at a reasonable cost. However, if promotion is merely a means of establishing market share, even when cheaper, therapeutically equivalent drugs are available, the promotion efforts may be socially harmful. Calcium Regulators ACTONEL QL DIDRONEL EVISTA FOSAMAX QL Estrogens MENEST ORTHO-PREFEST PREMARIN Estrogen Combinations ESTRATEST, HS PREMPHASE PREMPRO Progestins PROMETRIUM Misc. Endocrine CYTADREN DDAVP DOSTINEX METHERGINE SYNAREL and advair. Dofetilide was approved and marketed in 2000 for oral therapy of AF and flutter. In controlled trials of 1000 patients, 30% of patients with AF given a dosage of 500 g bid converted to sinus rhythm, compared to 6% in the control treated with sotalol and 1% of given placebo. Prevention of recurrence was demonstrated, with 62 to 71 % remaining in sinus rhythm after 6 months, compared to 59% for sotalol and 26 to 37% for placebo. The Danish Investigators of Arrhythmia and Mortality on Dofetilide, or DIAMOND trial1 in 1518 patients with reduced ejection fraction and symptoms of heart failure showed the drug to be safe with reduced incidence of hospitalization for heart failure.
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Bull; actonfl might be more effective than fosamax • less esophageal problems not none ; • brand new, hence, less well known long term side effects • studied for up to 3 years prevent osteoporosis • treat your bone mass like your retirement fund: – build it early – deposit often – keep it stocked – avoid loses choose a bone healthy lifestyle • daily weight bearing exercise encouraged • choose foods rich in calcium sources and low in sodium, phosphates, animal protein, caffeine, and nicotine bone health summary • maximize calcium intake – calcium supplements slow bone density loss – dairy products or other sources of calcium can help young women attain their peak bone mass – green leafy vegetables, calcium fortified soy products, and grains are “ the healthiest” sources of calcium • avoid factors that cause you to loose calcium – smoking, excess salt, caffeine, & animal protein intake • exercise mix aerobics with weight training. Prescription filled. There are many medications that may interfere with your transplant medications and lead to serious problems. Store your medicines out of the reach of small children. They could cause significant harm or even death if taken. If you vomit after taking your medicine, do not repeat those medications. Please call the transplant coordinator immediately. Please call your coordinator if headaches become a problem for you. If you develop sores that do not heal, or skin eruptions, warts, see a doctor or dermatologist. If you need medical treatment for the condition, please have the doctor call the transplant office to discuss the treatment. NEVER make changes or stop taking any medicine without checking with the transplant team first!!!!! DO NOT assume that you can stop taking any medications without talking it over with the transplant team and aldara. PAIN CONTROL Pain is one of the most feared symptoms of cancer. Chronic pain can significantly reduce your quality of life and make even simple tasks seem overwhelming. Pain can be caused by the effects of cancer in your body or may be a side effect of treatment. Regardless of the cause, good pain control is possible in nearly every situation. Many effective treatment options are available to control pain. Cancer pain has been well researched. Pain control has become a sophisticated science. Many advances have been made in the field of pain management in recent years. Oncology doctors and nurses are well trained in the both the assessment and treatment of pain. The first step toward effective pain control is telling your doctor or nurse about your pain. Although this may seem obvious, many people do not tell their providers about their pain until it becomes intolerable. Do not fall into the trap of thinking that telling your provider about your pain is a sign of weakness. Your health care team wants you to live your life as fully and normally as possible. While pain is an important way for the body to let you know something is wrong, chronic pain serves no useful purpose and can significantly disrupt your life. There is no reason to tolerate chronic pain in silence. Be sure to tell your health care provider about any new or changing pain you experience. Pain often changes over time. The location and severity of pain can be highly variable. Different types of pain require different treatments. In general, it is easier to achieve good pain control if the pain can be addressed early in its course rather than later when the pain becomes severe. The treatments, drugs, and dosages of drugs used to control pain are individualized to your specific symptoms. The goals of pain management are to minimize the experience of pain while limiting unwanted side effects from pain control treatments. When you talk with your health care provider about your pain, you will need to describe your pain. This helps your provider decide how best to treat you. Consider keeping a log of your pain, especially if your pain comes and goes. Important aspects of your pain should be recorded, for instance, risedronato. Because it caused lower back and muscle pain, i discontinued it and switched to acfonel and alendronate. Our top fifteen products in terms of net sales generated in 2006 are Lovenox, Plavix, Stilnox, Taxotere, Eloxatine, Lantus, Copaxone, Aprovel, Tritace, Allegra, Amaryl, Xatral, Actonel, Depakine and Nasacort which together accounted for 66.9% of our 2006 net sales for the pharmaceutical activity, or 17, 289 million. We are a major player in the vaccines industry, with net sales of 2, 533 million in 2006; and with leading vaccines in five areas: Pediatric combination vaccines providing protection against diseases such as pertussis, diphtheria, tetanus, and Haemophilus influenzae type b infections. Our main products are Daptacel, Tripedia, Act-HIB, Pentacel, Pediacel and Pentaxim. We are also a leading producer of poliomyelitis polio ; vaccines, such as Ipol and Imovax Polio, as well as oral polio formulations, all of which contribute to polio eradication and disease control strategies in both developed and developing countries; Influenza vaccines such as Fluzone and Vaxigrip, used for seasonal campaigns in both hemispheres. Additionally, we manufacture pre-pandemic avian influenza vaccines including H5N1 vaccines ; as part of the global pandemic preparedness efforts in both our French and U.S. facilities.
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