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Chemotherapeutics & PNS Sample Exam 1. Which of the following antiviral drugs could be described as a chain terminating pro-drug? A. Acyclovir B. Valacyclovr C. Pencyclovir D. Gancyclovir E. Valganciclovir 2. An asian patient is on medications for tuberculosis, but he is not getting better. What is a reasonable reason for him not getting better despite being prescribed anti-TB medications? A. One medication may be metabolized too quickly to an inactive, secreted product. B. He may have stopped taking one medication because he noticed his bodily secretions turned orange C. He may have stopped taking one medication because he noticed changes in his vision D. He may have developed a resistant form of TB due to noncompliance E. All of the above 3. You are monitoring a patient on a certain anticancer drug. Initially the patient experienced hand and foot syndrome, which you attribute to that drug. Now, however, the patient's cancer seems to have developed resistance to the drug in question. What enzyme was most likely to have mutated? A. Hypoxanthine-guanine phosphoribosyl transferase B. Xanthine oxidase C. Thymidylate synthase D. Dihydrofolic acid reductase E. CYP450 4. As a precocious second year medical student, you notice on a patient's chart that the patient is being administered Leucovorin. What is true about another drug that that patient is almost definitely receiving for cancer chemotherapy? A. The other drug looks nearly identical to folic acid B. The other drug is activated by HGPRT C. The other drug causes cardiotoxicity D. The other drug inhibits thymidylate synthase E. The other drug does not have significant CNS or hepato-toxicities 5. One of Dr. Clive's patients presents to you with an asymmetrically enlarged, painless testicle. After taking a careful history, he confides in you that he has adult polycystic kidney disease. His creatinine is 4.3. Which drug would you prescribe? A. Carboplatin B. Cisplatin C. Foscarnet D. Streptomycin E. Estrogen Mix and match: NRTI's more than once or not at all ; A. Zidovudine B. Didanosine C. Abacavir D. Stavudine E. Lamivudine F. Tenofovir 6. Which drug would base pair to Adenine? 7. Which drug has sensory neuropathy as a toxic effect? 8. Which drug is a nucleotide analog? 9. Which drug's base is inosine? 10. Which drug is an ester prodrug? 11. Which drug is used for both HIV and HBV therapy?.
It will outline the project benefits, lessons learned, and impact on patients, provider, communities and the health system. The evaluation report will be used as the basis to develop an academic paper s ; that may focus on particular aspects of the project or certain types of data collection. Finally, the results of the evaluation will be presented to various stakeholders as needed, because valacyclovir and pregnancy.

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Tuberculin, Purified Protein Derivative P.P.D. ; Intermediate test strength: 5 TU 0.1 mL Valacycolvir Valtrex ; Caplets: 500 mg, 1 g Valproic Acid Valproate Depakene ; Capsule: 250 mg Syrup: 250 mg 5 mL Vancomycin Vancocin ; Capsule: 125 mg, 250 mg Powder for oral solution: 1 g, 10 g Powder for injection: 500 mg, 1 g, 2 g, 5 g, 10 Varicella Virus Vaccine, Live Varivax ; Injection, single dose Venlafaxine Effexor ; Capsule, sustained release: 37.5 mg, 75 mg, 150 mg Tablet: 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg Verapamil Calan, Isoptin ; Capsule, sustained release: 120 mg, 180 mg, 240 mg, 360 mg Injection: 2.5 mg mL Tablet: 40 mg, 80 mg, 120 mg Tablet, sustained release: 120 mg, 180 mg, 240 mg Vitamin A Aquasol A ; Capsule: 10, 000 units, 25, 000 units, 50, 000 units Injection: 50, 000 units mL Tablet: 5000 units Vitamin A&D Ointment Ointment, topical: 113 g Vitamin B Complex Vitamin C Stresscaps, Allbee with C ; Capsule: each capsule contains a minimum of USDA requirements Tablet: each tablet contains a minimum of USDA requirements Vitamin B Complex Vitamin C Zinc Tablet: each tablet contains a minimum of USDA requirements Vitamin D Ergocalciferol, Calciferol, Drisdol ; Capsule: 50, 000 IU Drops, oral: 200 IU drop.
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The present shortage of IVIg results from many factors including the withdrawal of several well known brands from the market. The Red Cross and ZLB Bioplasma announced earlier last year that they would discontinue production of IVIg products. And in January 2006, after introducing its next generation products last year, Baxter announced that it will discontinue one of its IVIg products by January 2007. IgG America, a home infusion company near Baltimore, Maryland, reported in its Newsletter that it anticipates more changes in these products. The Plasma Protein Therapeutics Association PPTA ; , an organization established and supported by the global suppliers of plasma therapeutics, reports a 2 to weeks' supply of IVIg at the manufacturer level. Their supply information is updated frequently and is available on line at pptaglobal. A two-step random sampling procedure doctors patients ; was used to ensure inferences on the overall populations of doctors, treated patients and prescribed drugs. Means and standard deviations were calculated for quantitative variables and frequencies for qualitative findings. Means were compared by classical Student t-tests, one-way and two-way analyses of variance ANOVA ; . Proportions were assessed by chi-square tests for contingency tables. Linear correlation coefficient and regression meaSods were applied to measure the association between quantitative variables. In the case of missing data, calculations were always done on the number of observations available. All results were considered to be significant at p 0.05, but whenever needed, a Bonferroni correction was implicitly applied to account for multiple comparisons and ativan.

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The use of rats makes practical the evaluation of new psychoactive drugs for potential abuse early in their development.
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Women of childbearing age, treatment is aimed at achieving regular menstrual cycles, prevent future episodes, replenish iron stores, prevent serious long term consequences of anovulation, preserve desired fertility. Oral contraceptives or progestogen therapy are frequently used for this purpose. If anemia is present, iron supplementation may be recommended. If pregnancy is desired, ovulation induction may be attempted with medication. Women whose symptoms are severe and resistant to medical therapy may choose surgical treatments including endometrial ablation a procedure that burns or removes the lining of the uterus ; or hysterectomy.
In May 2003, the government declared victory over SARS in a series of measures that led to the relaxation of precautions on May 13 and the lifting of the provincial emergency on May 17. In fact, SARS was still with us, spreading undetected at North York General Hospital and ready to break loose with a vengeance when precautions were relaxed. How could Ontario declare victory when in fact it was on the edge of a fresh outbreak that would burst into public view on May 23, kill 17 more people and leave another 118 sick with SARS?453 The answer is not easy to find. Everyone wanted SARS to be over, and this desire no doubt influenced the decision to declare victory. The most identifiable cause for SARS II may be the lack of any formal effective surveillance program. Dr. Richard Schabas put it this way at the Commission's public hearings: Unfortunately, what we did was we flipped from a state of SARS panic to a state of SARS denial because as SARS I was petering out, we made the crucial error of not introducing any programme of active surveillance for SARS. In fact, it was worse than that . believe on May 8th the city health department announced that the outbreak was over. On May 12th the Chief Medical Office of Health for Ontario was quoted in the Toronto Star as saying "it was preposterous" his word, "preposterous" that someone could have acquired SARS in Toronto in late April . have to realize that with there being no programme of active SARS surveillance in Toronto, there was no basis for saying that the outbreak was over. It was, in fact, an exercise in wishful thinking and cialis.
New drugs added since June 2002 indicated in bold. ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx, Videx EC ; , emtricitabine Emtreva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanivir sufate Reyataz ; , fosamprenavir Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hydrea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , clarithromycin Biaxin ; , fluconazole Diflucan ; , foscarnet Foscavir ; , ganciclovir Cytovene ; , isoniazid INH ; , itraconazole Sporonox ; , leucovorin floinic acid ; , pyrimethamine Daraprim, Fansidar ; , sulfadiazine, TMP SMX Bactrim ; . Other OIs- amphotericin B, atovaquone Mepron ; , caspofungin Cancidas ; , clotrimazole oral Mycolex Troches ; , dapsone, erythropoietin alpha Epogen ; , ethambutol hydrochloride Myambutol ; , folinic acid Leucovorin calcium ; , rifabutin Mycobutin ; , nystatin Mycostatin ; , pentamidine NebuPent Pentam ; , pyrazinamide Rifater ; , rifampim If not covered by County Health ; , Valaacyclovir Valtrex ; , valganciclovir Valcyte ; . Hepatitis C- none TREATMENTS FOR METABOLIC DISORDERS Wasting- megestroll acetate Megace ; , estosterone. Hyperlipidemia- atorvastatin Lipitor ; , gemfibrozil Lopid ; , pravastatin Pravachol ; . Other- amitriptyline Elavil ; amoxapine Ascendin ; , aripiprazole Abilify ; , bupropion Wellbutrin Wellbutrin SR ; , buspirone BusPar ; , carbamazepine Tegretol Tegretol XR ; , chlorpromazine Thorazine ; , citalopram Celexa ; , clomipramine Anafranil ; , clozapine Clozaril ; , desipramine Norpramin ; , doxepin Sinequan ; , filgrastim Neupogen ; , fluoxetine Prozac ; , fluphenazine Prolixin ; , fluvoxamine Luvox ; , gabapentin Neurontin ; , haloperidol Haldol ; , hydroxyzine Atarax Vistaril ; , imipramine Tofranil ; , isocarboxazid Marplan ; , lamotrigine Lamictal ; , lithium Eskalith ; , loxapine Loxitane ; , maprotiline Ludiomil ; , mesoridazine Serentil ; , mirtazapine Remeron ; , molindone Moban ; , nefazodone Serzone ; , nortriptyline Pamelor ; , olanzapine Zyprexa ; , oxcarbazepine Trileptal ; , paroxetine Paxil Paxil CR ; , perphenazine Trilafon ; , phenelzine Nardil ; , pimozide Orap ; , promazine Sparine ; , protriptyline Vivactil ; , quetiapine Seroquel ; , risperidone Risperdal ; , sertraline Zoloft ; , sodium divalproex Depakote ; , thioridazine Mellaril ; , thiothixene Navane ; , tiagabine Gabatril ; , topiramate Topamax ; , tranylcypromine Parnate ; , trazodone Desyrel ; , trifluoperazine Stelazine ; , triflupromazine Vesprin ; , trimipramine Surmontil ; , valproic acid Depakene ; , venlafaxine Effexor Effexor XR ; , voriconazole Vfend ; , ziprasidone Geodon.

Valacyclovir study

ABSTRACT The Herpesviridae family Types 1-8 ; continues to inflict considerable morbidity and social stigma upon humanity. Once infected with the herpes viruses, especially Types 1-3, they establish permanent residence within our nervous system and reactivate during periods of stress, trauma, and or other precipitating factors. To date, there is no cure for herpes viral infections but antivirals can attenuate the symptoms and duration of episodic outbreaks. Prophylactic therapy can suppress recurrences. The first antiviral with selective activity against virus-infected cells is considered to be acyclovir. Our article will highlight the clinical indications of the current generation, valacyclovir, which is a prodrug of acyclovir. We consider valacyclovir as a second-generation antiviral, having taken into account the initial selectivity and safety profile of its progenitor, acyclovir. Keywords: herpes virus, antiviral, herpes simplex, varicella-zoster and danazol.

Maprotiline and breastfeeding breastfeeding women who are taking maprotiline may pass the drug to the nursing child through breast milk.

This pro-drug is metabolized to acyclovir and L-valine with better oral absorption than acyclovir. Use with caution in hepatic or renal insufficiency. Adjust dose in renal insufficiency see p. 96 ; . Thrombotic thrombocytopenic purpura hemolytic uremic syndrome TTP HUS ; has been reported in patients with advanced HIV infection and in bone marrow and renal transplant recipients. Probenecid or cimetidine can reduce the rate of conversion to acyclovir. See acyclovir for additional drug interactions and adverse effects. For initial episodes of genital herpes, therapy is most effective when initiated within 48 hr of symptom onset. Therapy should be initiated immediately after the onset of symptoms in recurrent episodes no efficacy data when initiating therapy 24 hr after onset of symptoms ; . Data are not available for use as suppressive therapy for periods 1 yr. Valacyclocir CANNOT be substituted for acyclovir on a one-to-one basis. Doses may be administered with or without food and darvon. Sultant in clinical ethics. When a trainee expresses concern about ethical issues, refuses to participate in activities related to care for patients or clinical teaching on the basis of ethical grounds, or seeks consultation on an ethical issue, this will have no repercussions for the trainee. The value of any guideline is not in how artfully it is crafted but in how well it is implemented and what effect it has. This is particularly critical in an area such as the role of ethics in medical education, where the informal curriculum reigns, and deep cultural change is needed. In considering the Coldicott study, we should follow the lessons of the medical error movement, since the paper reports a type of ethical error in medical education. Rather than seeking to fix blame, we should try to find systemic solutions to the ethical challenges of medical education. Each medical school should develop and implement guidelines for ethics in clinical teaching, evaluate their impact, and share the findings of these evaluations. Peter A Singer Sun Life financial chair and director, for example, valacyclovir herpes.

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Moods, and drug-related medical, psychiatric, and legal needs and deltasone. If neither botox nor medicine is effective, surgical removal of some of the eyelid muscles is corrections & amplifications - dec 15, 2006 wall street journal subscription ; , two medications used by gregory thompson, a death-row inmate profiled in a page-one article thursday, were misspelled, for example, valacyclovir acyclovir or famciclovir. For the current section - home my at& t e-mail features search tools shop anywho member services help health home health news health news health videos health a-z health encyclopedia health store alternative medicine better living diet center fitness center healthy recipes nutrition center parenting center pregnancy center sexual health all channels breast cancer - treatment news - the basics symptoms detection & treatment prevention how do i know if i have breast cancer and desyrel.
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490. Age-related changes in human postural control of prolonged standing - Freitas S.M.S.F., Wieczorek S.A., Marchetti P.H. and Duarte M. [M. Duarte, Laboratory of Biophysics, School of Physical Education and Sport, University of S~ o Paulo, Av. Prof. a Mello de Moraes 65, S~ o Paulo, SP 05508-030, Brazil] - GAIT a POSTURE 2005 22 4 ; - summ in ENGL The aim of this study was to characterize prolonged standing and its effect on postural control in elderly individuals in comparison to adults. It is unknown how elderly individuals behave during prolonged standing and how demanding such a task is for them. We recorded the center of pressure COP ; position of 14 elderly subjects and 14 adults while they performed prolonged standing 30 min ; and quiet stance tasks 60 s ; on force plate. The number and amplitude of the COP patterns, the root mean square RMS ; , speed, and frequency of the COP sway were analyzed. The elderly subjects were able to stand for prolonged periods but they produced postural changes of lesser amplitude and a decreased sway during the prolonged standing task. Both the adults and the elderly subjects were influenced by the prolonged standing task, as demonstrated by their increased COP RMS and COP speed in the quiet standing trial after the prolonged standing task, in comparison to the trial before. We suggest that the lack of mobility in elderly subjects may be responsible for the observed sub-optimal postural changes in this group. The inability of elderly individuals to generate similar responses to adults during prolonged standing may contribute to the increased risk of falls in the older population. 2004 Elsevier B.V. All rights reserved. 491. The dinucleotide CA ; repeat polymorphism of estrogen receptor beta but not the dinucleotide TA ; repeat polymorphism of estrogen receptor alpha is associated with venous ulceration - Ashworth J.J., Smyth J.V., Pendleton N. et al. [G.S. Ashcroft, Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom] - J. STEROID BIOCHEM. MOL. BIOL. 2005 97 3 ; - summ in ENGL Venous ulcers are the predominant form of chronic wound in the elderly, accounting for around 70% of all cases. The steroid sex hormone estrogen plays a crucial role in normal human skin maintenance and during cutaneous wound repair following injury. Estrogen can reverse age-related impaired wound healing by dampening the inflammatory response and increasing matrix deposition at the wound site. The molecular actions of estrogen are mediated through two nuclear sex steroid hormone receptors, estrogen receptor alpha ER ; and beta ER ; . We have conducted a case-control study to investigate whether dinucleotide repeat polymorphisms in the estrogen receptor genes are associated with venous ulceration in the UK Caucasian population. Genomic fragments containing the ER dinucleotide TA ; n repeat polymorphism or the ER dinucleotide CA ; n repeat polymorphism were amplified by polymerase chain reaction in subject DNA samples and genotyped according to fragment length by capillary electrophoresis. There was no evidence to suggest that the TA repeat polymorphism of ER was associated with venous ulceration. However, the CA 18 allele of the ER CA repeat polymorphism was significantly associated with venous ulceration n 120, OR 1.8, 95% CI 1.1-2.8, P 0.02 ; . When the CA repeats alleles were grouped together into either low L 18 ; or high H 18 ; numbers of CA repeats, the low L ; repeat. Company has taken unprecedented steps in promoting the replacement of Zovirax, by advertising on television for viewers to call a toll-free number to qualify for free-trial samples, by taking out full page ads in numerous magazines also including the free-trial offer ; , and by arranging for the inclusion of glossy insert ads for my campus newspaper and I would bet other campus newspapers as well ; . I have never seen such an advertising blitz for a prescription drug before. A little explanation is in order here. It begins with the fact that the active ingredient of Zovirax acyclovir, which I will discuss shortly ; was patented in 1980 by Burroughs Wellcome Co. a.k.a., GlaxoSmithKline ; . This patent, No. 4199574, "Methods and compositions for treating viral infections and guanine acyclic nucleosides" ; recently expired. Such patents are generally good for 17 years. ; This means that other pharmaceutical companies can now manufacture generic acyclovir, which means that it is currently available more cheaply than it was under the name Zovirax. Since GlaxoSmithKline has `lost' ownership of the product, the company has invented replacement products which it has also patented. So now the company promotes the replacement products, which are covered under current patents, more or less going about their business as if Zovirax never existed. So what are the replacement products? The main one is called Valtrex, which contains the active ingredient alacyclovir hydrochloride. It is no coincidence that this name is so similar to acyclovir. In non-technical lingo, I would describe valzcyclovir as the same thing as acyclovir but with an extra chemical doohickey attached to it in this case, the doohickey is an amino acid called L-valine ; . Indeed, as soon as valacyclovri goes into the body, it immediately loses the doohickey and becomes acyclovir itself! So the most significant difference between the two is that GlaxoSmithKline holds a current patent on one valacyclovir ; but not on the other acyclovir ; . That is why the company is blitzing the market with their `new' treatment for herpes. This drug is covered by patent number 4957924 "Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof" ; , which was granted in 1990. You can expect yet another `new' product to come along before this patent expires. ; For the purposes of this book, therefore, my discussion of Zovirax applies equally to Valtrex and any other similar new product that is derived from acyclovir. Medical Economics Company of Montvale, New Jersey, publishes the Physicians' Desk Reference, which describes drug dosages, effects, and side effects. This is an important resource for every doctor and every patient, although patients do not generally own it. You can find one in the reference section of almost any public library. In the 1996 edition, you will find that and imovane and valacyclovir. Valacyclovir and valganciclovir with specificity constants kcat Km ; , 420 and 53.2 mM-1s-1, respectively. We conclude that BPHL may be an important enzyme activating valacyclovir and valganciclovir in humans and an important new target for prodrug design. Medical and psychiatric illnesses Elderly people are more likely to have medical problems as previously discussed in this chapter and to be on multiple medications. Depression is common in the elderly. This is sometimes the result of chronic medical illnesses, which reduce the person's function, the loss of family members and the change of role in society. Elderly people living in hostels or nursing homes are particularly at risk of insomnia because many of the factors and lasix. CHD and stroke remain the major causes of death in people over the age of 65 years, with hypertension the commonest treatable risk factor. Trial data show that older people have benefited as much, if not more, from such interventions as younger individuals. Elderly patient usually have ISH isolated systolic hypertension ; . Thiazide and or Calcium channel blockers are treatment of choice. Treatment should be given at least up to age 80 years at least. Women who i've talked to who made this choice now have happy healthy children.

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New drugs added since June 2002 indicated in bold. ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, HIVID ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . nNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hydrea ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , cidofovir Vistide ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , foscarnet Foscavir ; , ganciclovir Cytovene ; , itraconazole Sporonox ; , leucovorin, pyrimethamine, sulfadiazine, TMP SMX Bactrim, Cotrim, Septra ; . Other OIs- amoxicillin, amoxicillin clavulanate Augmentin ; , amphotericin B, Fungizone ; , atovaquone Mepron ; , ciprofloxacin Cipro ; , clindamycin, clotrimazole Mycelex ; , dapsone, epoetin Alfa Epogen Procrit ; , ethambutol Myambutol ; , formivirsen Vitravene ; , ketoconazole Nizoral ; , ofloxacin Ocuflox ; , penicillin, pentamidine Nebupent, Pentam ; , primaquine, rifabutin Mycobutin ; , terbinafine Lamisil ; , valacyclovir Valtrex ; , valganciclovir Valcyte ; . Hepatitis C- interferon alpha-2A Roferon-A, Intron-A ; , pegylated interferon Peg-Intron ; , ribavirin Rebetron ; . TREATMENTS FOR METABOLIC DISORDERS Cardiac- amlodipine Norvasc ; , atenolol Tenormin ; , diltiazem Cardizem ; , enalapril Vasotec ; , furosemide Lasix ; , hydrochlorothyazide, lisinopril Zestril ; , metoprolol Lopressor Toprol ; , minoxidil Loniten ONLY ; , nifedipine Procardia ; , quinapril Accupril ; , ramipril Altace ; , verapamil Isoptin ; . 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Removed 2002- diphenoxylate Lomotil ; , loperamide Imodium ; , megestrol acetate Megace ; , prochlorperazine Compazine ; , trimethobenzamide Tigan and ativan.
Valacyclovir oral
Data demonstrate that oral acyclovir, valacyclovir, or famciclovir is superior to placebo. Intravenous acyclovir has been shown to prevent disease progression in patients at high risk for dissemination 55, 77 ; . However, for mildly to moderately immunocompromised persons, oral valacyclovir or famciclovir with careful patient observation ; may be acceptable alternatives to intravenous treatment. The ongoing debate about the role of corticosteroids in the management of zoster has been addressed in two well-controlled trials 78, 79 ; . Small or uncontrolled studies initially suggested that steAnnals of Internal Medicine.
This study was designed to determine if maintenance valacyclovir administration to patients with genital HSV-2 infection effectively prevents transmission to sexual partners. This trial involved 1484 immunocompetent, heterosexual, monogamous couples who were serologically discordant for symptomatic genital HSV-2. The couples were randomly assigned to receive valacyclovir 500 mg d ; or placebo for 8 months. The susceptible partner was evaluated monthly for signs and symptoms of genital herpes. A subset of participants who were monitored for recurrences of genital herpes n 89 ; also had viral cultures to determine the frequency of daily HSV viral shedding in genital secretions. Couples were counseled on safer sex practices and were offered condoms. At the end of the study, the incidence of HSV transmission to the healthy partner was significantly lower among the valacyclovir recipients than among the controls; outcomes were determined by the presence of HSV symptoms 0.5% vs. 2.2% ; , incidence of newly acquired HSV seropositivity 1.9% vs. 3.6% ; , and evidence of viral shedding 2.9% vs. 10.8% ; . The authors concluded that oncedaily suppressive therapy with valacyclovir reduced the frequency of HSV transmission to sexual partners. On the basis of these findings, the U.S. Food and Drug Administration FDA ; approved valacyclovir for prevention of HSV transmission as well as prevention of outbreaks of HSV infection 7 ; . However, physicians should remain aware that these new indications cannot be expanded to include nonheterosexual persons or those who are immunocompromised until more research is conducted. These findings do raise the promising possibility that valacyclovir could have a role in preventing transmission of HIV because of the large risk associated with HSVinduced ulcers.

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