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Beginning next year, we will use a new five-year Indian Health Service diabetes grant to conduct a Cardiovascular Disease Risk Reduction Demonstration Project in various community settings, including the new Center for the Physically Limited. Our "Heart Savers" cardiovascular disease risk reduction program for American Indians living with diabetes will promote healthy eating and increased physical activity. BIRD" FLU President, Dr. Julie Frazier met with the Governor's Office on April 10, 2006 regarding a vaccine for the "Bird Flu" epidemic. Dr. Frazier noted that no vaccine has been developed to warrant against this type of flu and it would probably be six 6 ; months or so before a vaccine is developed. BRAD BECK, DPH HACIENDA HEIGHTS, CA Dr. Brad Beck personally appeared before the Board to discuss an action taken by the Board at the November 14 - 15, 2000 board meeting in regards to a complaint and to request a change in his Tennessee pharmacist license status from inactive to active. Dr. Beck noted the Nevada Board of Pharmacy had taken disciplinary action against his license for Medicaid fraud. Dr. Beck noted the felony conviction had been expunged but an OIG restriction had been placed on his license. After board discussion, Dr. Sheila Mitchell motioned to postpone the request, seconded by Dr. Reggie Dilliard. All were in favor and the motion carried. The Board suggested Dr. Beck apply to HHS to have the exemption lifted. DIRECTOR'S REPORT MR. NEIL LAWLEY Cherokee Health Sustem Pharmacy 501 Adesa Boulevard #A-150 Lenoir City, TN 37771 Dr. Neil Lawley, pharmacy service coordinator with Cherokee Health System Pharmacy, submitted a request for approval for a pharmacy policy and procedure for remote access of pharmacy services. Cherokee Health Systems has several 330 CHC FQHCLA and will have two 2 ; in-house 340b pharmacies. Cherokee Health Systems would like to be able to fill a prescription at one of the in-house pharmacies and deliver it to the clinic site for patient pick-up. Cherokee Health Systems will be installing register software at each facility which is connected to the pharmacy software and will have the ability to capture the patient signatures that can be retrieved at the pharmacy. The Board expressed concern with patient counseling and Rule 1140-3-.05 relevant to areas of receipt and dispensing. The Board referred the matter to Chief Legal Counsel, Mrs. Alison Cleaves for action and meridia. 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The membranes were blocked with 1 TBST [20 mmol L Tris-HCl pH 7.6 ; , 8.5% NaCl, 0.1% Tween 20] containing 5% nonfat dry milk at room temperature for 2 hours and incubated in the appropriate primary antibody in 1 TBST containing 5% nonfat dry milk at 4jC overnight. RXRg Y-20 ; primary antibody and PPARg E-8, catalogue no. 7273 ; monoclonal antibody were obtained Santa Cruz Biotechnology, Santa Cruz, CA ; . We used 6.6 Ag 1: 500 dilution ; of RXRg and 0.13 Ag 1: 500 dilution ; of PPARg primary antibody for overnight incubation. After washing, membranes were incubated for 1 hour at room temperature with antirabbit IgG conjugated to peroxidase at a 1: 5, 000 dilution for RXRg and antimouse IgG conjugated to peroxidase at 1: 5, 000 dilution for PPARg. The enhanced chemiluminescence detection reagent Amersham Biosciences, Piscataway, NJ ; was used for immunodectection. Immunoprecipitation Cells f12 13 million ; were used for each immunoprecipitation experiment. The cells were washed in cold PBSEDTA, and solubilization buffer 1 mL ; was added [buffer contents: 55 mmol L TEA pH 7.5 ; , 111 mmol L NaCl, 2.2 mmol L EDTA, 0.44% SDS]. The solution was passed through a 20 G syringe five times, frozen at 80jC for 3 hours, and thawed on ice. Triton X-100 10%, 80 AL ; was added followed by protein A G plus agarose beads 80 AL, sc-2003, Santa Cruz Biotechnology ; . The mixture was shaken at 4jC for 8 hours. The suspension was spun for 2 minutes at 10, 000 rpm to pellet the beads, and the supernatant was removed. PPARg 5 AL or 200 Ag mL, H-100 ; rabbit polyclonal antibody sc-7196, Santa Cruz Biotechnology ; was added followed by protein A G plus agarose beads 80 AL ; . This was again shaken at 4jC for 8 hours and spun to remove the supernatant. This mixture was washed twice with a wash buffer [50 mmol L TEA pH 7.5 ; , 100 mmol L NaCl, 2 mmol L EDTA, 0.1% SDS, 0.5% Triton X-100] and washed twice with 10 mmol L TEA pH 7.5 ; . The bound antigen was eluted by adding the Western blot 1 sample buffer, heated for 5 minutes at 100jC, and loaded onto a SDS-PAGE gel for Western blot analysis. The methods are the same as above, except for the PPARg antibody concentration at 1: 500. Cell Growth and Proliferation Cells were grown to f80% confluence in 100 mm tissue culture plates. Cells were harvested using trypsin-EDTA Invitrogen ; and counted using a hemocytometer. Cells were transferred to a 96-well plate at a concentration of 500 cells per 200 AL of medium. Each row of eight wells received the same cell type and subsequently the same drug. After cells were allowed to plate down overnight, the medium was aspirated and medium with the appropriate concentration of ligand or equivalent volume of vehicle and mesterolone. To gain admission to a nursing home the person who has a mental illness must be evaluated to determine if a nursing home is appropriate ; by a PAS-MH Pre-Admission Screening ; agency. 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Equal opportunities Based on international conventions Novo Nordisk defines equal opportunities as "equal opportunity in recruiting, terms of employment, promotion, and termination is practised without any distinction, exclusion or preference made on the basis of gender, sexual orientation, age, disability, marital status, religious beliefs, creed, colour, race or ethnic origin or political orientation, except when justified by requirements intrinsic to a specific job". Global Compact is a UN-sponsored platform for encouraging and promoting good corporate practices and learning experiences in the areas of human rights, labour and the environment. Global Reporting Initiative GRI ; is an international, multistakeholder effort to create a common framework for voluntary reporting of the economic, environmental, and social impact of organisation-level activity. It is convened by the Coalition for Environmentally Responsible Economies CERES ; in partnership with the United Nations Environment Programme UNEP ; . GMM and GMO Genetically Modified Microorganisms GMMs ; are a subgroup of Genetically Modified Organisms GMOs ; . At Novo Nordisk microorganisms such as bacteria Bacillus, E. coli ; and microfungi yeast, Aspergillus ; have been encoded with genes for producing pharmaceutical proteins. GMMs are classified as safe or demonstrating the lowest potential risk only if certain criteria are fulfilled according to the scientific risk analysis. The GMM must not be pathogenic to humans, animals or plants, or in any way harmful to the environment. Further, the original microorganism should be non-pathogenic, and the genes inserted should not be expected to cause any harm. Social responsibility is about improving the quality of relations with key stakeholders. Novo Nordisk defines it as putting values into action in the perspective of human resources, human rights, health & safety, and our relations with society at large. Stakeholder A stakeholder is an individual, a group of individuals or an organisation affected by or affecting the behaviour of a company or an organisation. Novo Nordisk's most significant stakeholder groups are shareholders, employees, customers, suppliers, the media, authorities, non-governmental organisations and local communities around our production sites. Sustainable development was defined in the Brundtland report from 1987 as "development that meets the needs of the present world without compromising the ability of future generations to meet their own needs". Novo Nordisk interprets this definition as the Triple Bottom Line approach. Triple Bottom Line The Triple Bottom Line concept reflects an integrated understanding of business performance, in which social, environmental and economic bottom lines are interdependent. The aim of a Triple Bottom Line approach is to ensure a business performance that is socially responsible, environmentally sound and economically viable.
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