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Oscar M. Reinmuth, MD. Editor Provides reports of clinical and basic investigations on all aspects of cerebral circulation and its diseases. The journal includes discussions from many disciplines, including neurology, radiology, nuclear medicine, neuropathology, neurosurgery, epidemiology, vascular surgery, rehabilitation, vascular physiology, neuropsychology, speech pathology, and neuro-ophthalmology.
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Of postmenopausal osteoporosis. IV ibandronate is administered by a health care professional once every three months. The process takes 15 to 30 seconds. This formulation offers an alternative for patients who have difficulty with oral bisphosphonate dosing requirements, including an inability to sit upright for 30 to 60 minutes or to swallow tablets. The FDA approved the IV form based on results of the DIVA study Dosing IntraVenous Administration ; . This clinical trial enrolled 1, 358 postmenopausal women with osteoporosis. The average increase in lumbar spine bone mineral density at one year with the injection 3 mg once every three months ; was statistically superior to that with the daily oral tablets 4.5% vs. 3.5% for the two treatments, respectively; P .001 ; . Patients receiving the IV form also had consistently higher bone density increases in the total hip and other sites than patients taking the oral daily form. The FDA approved once-monthly ibandronate as the first once-a-month tablet for postmenopausal osteoporosis in March 2005. The injection will be available in early 2006. Source: Roche, January 6, 2006.
Paul Sexton, appointed to the post of GMP Manager; Dr. Patrick Costello, appointed to the post of Blood Tissues Manager; Dr. Lorraine Nolan, appointed to the post of Controlled Drugs GDP Manager; Ms. Celine Creighton, appointed to the post of GCP Pharmacovigilance Inspection Manager. Ms. Lisa Anne Byrne and Ms. Deirdre O'Regan have joined the GCP Pharmacovigilance Inspections section, and Mr. Gerard Sheridan has taken up a position in the GMP Inspection section. Mr. Stan O'Neill, Senior Inspector, will lead on issues relating to Sterile GMP and will represent the IMB at the ad hoc Working Party of GMP Inspection Services at the EMEA, for instance, prednisone.
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Synopsis According to a report in the New England Journal of Medicine, abdominal liposuction does not significantly improve obesity-associated metabolic abnormalities. In this small study, researchers evaluated the effect of large-volume abdominal liposuction on metabolic risk factors for coronary heart disease in women with abdominal obesity before and 10 to 12 weeks after the procedure. Eight of the women had normal glucose tolerance mean BMI 35.1 ; , and seven had type 2 diabetes BMI 39.9 ; . The following data were reported: Liposuction decreased the volume of subcutaneous abdominal adipose tissue by 44% in the subjects with normal glucose tolerance and 28% in those with diabetes. Those with normal oral glucose tolerance lost 9.1 kg of fat 18% decrease in total fat, P 0.002 ; , and those with type 2 diabetes lost 10.5 kg of fat 19% decrease in total fat, P 0.001 ; . Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue and did not significantly alter plasma concentrations of C-reactive protein, interleukin-6, tumour necrosis factor alfa, and adiponectin; Liposuction did not significantly alter other risk factors for coronary heart disease blood, pressure, plasma glucose, insulin, and lipid concentrations ; . The researchers conclude that decreasing adipose tissue mass alone will not achieve the metabolic benefits of weight loss. Title Source Synopsis.
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Communication might instead "throw a temper tantrum" as she is dragged to the dinner table. A typical child riding in a stroller through the mall while Mom shops might scream, "No stop, Mommy!" each time the stroller comes to a halt. A child without verbal communication with similar feelings might bang her head on the stroller in desperation to communicate the same message. A typical child might say, "But you know I don't like peas!" when the little green things appear on the dinner plate, while a child without more appropriate communication strategies might spit out the peas when they are spooned into her mouth. In these examples, the "temper tantrum, " head banging, and spitting are communication. What we want to find are ways to replace them with more acceptable and efficient ways of communicating.
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SHADOW RING, THE: Lighthouse 2LP SWILL 017 ; . $15.00 First album in a while from the UK-centered group previous documentation via their own Dry Leaf label, Corpus Hermeticum & Siltreeze ; . Assisting the core members Lambkin, Harris, Goss ; on this recording from `97-'98 ; are the following Americans: Adris Hoyos, Karla Borecky & Scott Foust Idea Fire Co. ; . "To enter the world of the Shadow Ring is to enter a surreal anti-world of bizarre song structure. Lighthouse will rank with Trout Mask Replica and Tago Mago as both one of the most avant garde and the most eccentric double LP's of all time. Unlike those two records, Lighthouse features no instrumental pyrotechnics, instead relying on odd sonic combinations, startling lyrics, and a very painterly use of minimal studio technology. Absolutely essential listening if you are interested in modernist stretching of song form with extraordinary results." IDEA FIRE COMPANY: Anti-Natural LP SWILL 018 ; . $11.00 "Idealized field recordings that capture the hallucinatory isolation of an abandoned arctic base. Anti-Natural combines organic mechanistic processes into an aesthetic whole. Both severe and opulent, nave and self-confident, Anti-Natural offers an escape route from the false dichotomies of man nature and man machine and attempts the transcendence of the impossible. Electronic recreations of the world around us, both real and imagined, foment immutable revolutions in sound." TART: Radio Orange LP SWILL 019 ; . $12.00 "The debut LP from the trio of: Karla Borecky, Graham Lambkin, and Scott Foust. Tart is an exquisite combination of three distinct minds, much like the skillful structure of diverse, yet subtle, ingredients in a piquant and nostalgic recipe: The Past as well as The Future. Tart blends together these strange elements in an organic yet totally disciplined style that renders many of their contemporaries as either flabby or boring. Radio Orange presents 7 original pieces of expertly edited new music-form. From the opening tape-collage miniatures, `The Rabbits of Mangtarau' pts 1 &2 ; , through to the indeterminacy and excitement of the closing title-track, Radio Orange carves its identity through great use of diversified expression. The analog drone vox duet: `Astride Such Delicate Pins'; the bizarre environmental action, `Woman In Her Womb'; the fragile tone composite, `The Mums'; and the grinding electronic surge of the almost 20 minute ; ' Chopin in a Shell' all help complete the program in classic style. The overall sound is both hypnotic and explosive, with each side being carefully sequenced to maximize the fact. The super-modernist avant garde continues to raise its aesthetic head under the romantic banner of the Anti-Naturals. Tart is fabulous." EARLY W: Volume 2: Nur Die Tiere Blieben Ubrig LP SWILL 020 ; . $13.00 "Volume two in a Swill Radio series of LP's documenting the early work of Ralf Wehowsky aka RLW ; . As with volume one, a slightly different version of this LP was originally released on cassette by Wahrnehmungen later renamed Selektion ; in the early 80's. This is a much more band-oriented release than volume 1. A number of tracks were recorded live and the mood is aggressive throughout. This is a fantastic Neue Deutsche Welle document. If it had been released on LP, it would be legendary. It still is." SHADOW RING, THE: Lindus LP SWILL 021 ; . $13.00 "Long delayed follow-up to Lighthouse. Over the last decade no other band have prompted such strong reaction as The Shadow Ring. Loved or hated, their unique and powerful sound has been totally impossible to ignore. Lindus sees that sound polarized to its logical and most satisfying extreme. Strange, claustrophobic sound-worlds build and overlap, creating a listening environment that is uncompromising, disturbing, yet always original. The mood is bleak and deflated throughout, providing a stark contrast to the carnival that was Lighthouse. The simple use of synths, electronics, tapes and voice has never been more effective. The Shadow Ring are that rare thing: a true underground band unaffected by trend or whim, and Lindus is their most supreme statement yet. Special edition of 500 copies." TART: Bring In The Admiral LP SWILL 022 ; . $13.00 "Tart Graham Lambkin, Karla Borecky, and Scott Foust ; presents the world with their second LP, Bring In The Admiral. Using the same minimal instrumentation as the live shows two small casios, guitar, and a shortwave cassette boombox plus a few studio effects and The Anti-Naturals trademark: tight, subtle, and yet powerful editing ; , Tart produces a dazzling array of scenarios, a testament to deranged beauty. Tart is a band that truely does not sound like anyone else and selegiline.
KIM WAALDERBOS Expanding waistlines may best be controlled with a glass of milk, say University of Toronto researchers. That could be good news for the 60 per cent of North Americans who are considered overweight or obese. Studies have shown a positive relationship between the consumption of dairy products and ideal body weight. Milk has also been found to be effective in high-protein weight-loss diets. But Prof. Harvey Anderson and research associate France Cho of the Department of Nutritional Sciences say it's not necessarily the high protein in diets that benefits human health but rather selecting for the right proteins. The researchers are studying how specific food proteins affect intake and reduce hunger in humans and rats. They believe certain milk proteins such as whey and casein may be particularly beneficial in helping consumers feel full and satisfied, staving off the desire to eat more. "Milk is very well-designed to give a quick feeling of satiety, " says Anderson. "It contains those two key proteins, which strongly suppress hunger." The researchers' study group consisted of young men who ate complete milk, soy and egg proteins, as well as casein and whey both derived from milk ; . The researchers found that complete milk and whey protein had the strongest ability to suppress the men's desire to eat within the following 90 and 150 minutes. Casein was also effective, but it didn't provide such immediate satiation. Anderson and Cho say their findings can be used to develop functional foods, products that are enhanced to offer health benefits beyond their basic nutrition. They foresee whey and casein proteins of milk being incorporated into other foods to make use of these beneficial properties. Whey, a byproduct of cheese making, is readily available for such purposes. This could ultimately add new products to the market to help consumers with weight control. Until new products are developed, however, Anderson says people concerned about their weight and wanting satiation should increase their milk consumption. "The best thing a hungry person could do after a long day is to have a big glass of milk to tide them over until supper." This research is funded by a Bristol-Myers Squibb Freedom to Discover Grant, the Ontario Ministry of Agriculture and Food, and Science and Engineering Research Canada. Others involved in this research include graduate students Alfred Aziz, Alireza Jahanmihan, Shannon Moore and Sharon Peng.
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10. Detection of Toxicity to Reproduction for Medicinal Products. In: ICH Harmonised Tripartite Guideline; 24 June 1993: Endorsed by the ICH Steering Committee at Step 4 of the ICH Process; 24 June 1993. p. 5. 11. Nuradilah M, Sani MNH, Anom HS, Balaspramaniam A, Aliah T, Nazaimoon WMW. Effects of Kacip Fatimah water extract on hormonal profile of normal female rats. The 4th International Traditional Complementary Medicine Conference and Exhibition INTRACOM 2002 ; 2002, Sunway Pyramid Convention Centre. 12. Paumgartten FRJ, De-Carvalho RR, Souza CAM, Madi K, Chahoud I. Study of the effects of B-myrcene on rat fertility and general reproductive performance. Brazillian Journal of Medical and Biological Research 1997; 31: 955-965. World Health Organization WHO ; . Environmental Health Criteria. Principles for evaluating health risks to reproduction associated with exposure to chemicals, ed: WHO World Health Organization ; , 2001: 1-187. 14. Manson JM, Zenick H, Costlow RD. Teratology test methods for laboratory animals. In: Hayes AW, ed. Principles of toxicology. New York, Raven Press, 1982: 141-184.
FUROSEMIDE EFFECTS ON SMOOTH MUSCLE 12. Knox AJ and Ajao P. Effect of frusenide on airway smooth muscle contractility in vitro. Thorax 45: 856859, 1990. Lundergan CF, Fitzpatrick TM, Rose JC, Ramwell PW, and Kot PA. Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide. J Pharmacol Exp Ther 246: 102106, 1988. Miyanoshita A, Terada M, and Endou H. Furosemide directly stimulates prostaglandin E2 production in the thick ascending limb of Henle's loop. J Pharmacol Exp Ther 251: 1155 1159, Mulvany MJ and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 1926, 1977. Nichol GM, Alton EWF, Nix A, Geddes DM, Chung KF, and Barnes PJ. Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Rev Respir Dis 142: 576 580, O'Connor BJ, Chung KF, Chen-Wordsdell YM, Fuller RW, and Barnes PJ. Effect of inhaled furosemide and bumetanide on adenosine 5 -monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Rev Respir Dis 143: 13291333, 1991. Pasargiklian M, Bianco S, and Allegra L. Clinical, functional and pathogenetic aspects of bronchial reactivity to prostaglandins F2 , E1 and E2. Adv Prostaglandin Thromboxane Res 1: 461475, 1976. Pasargiklian M, Bianco S, and Allegra L. Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients. Respiration 34: 7891, 1977. Robuschi M, Gambaro G, Spagnotto S, and Bianco S. Inhaled frusemide is highly effective in preventing ultrasonically nebulized water bronchoconstriction. Pulm Pharmacol 1: 187 191, Salari H and Chan-Yeung M. Release of 15-hydroxyeicosatetraenoic acid 15-HETE ; and prostaglandin E2 by cultivated human bronchial epithelial cells. J Respir Cell Mol Biol 1: 245250, 1989. Solway J and Leff AR. Sensory neuropeptides and airway function. J Appl Physiol 71: 20772087, 1991. Stevens EL, Uyehara CFT, Southgate WM, and Nakamura KT. Furosemide differentially relaxes airway and vascular smooth muscle in fetal, newborn, and adult guinea pigs. Rev Respir Dis 148: 11921197, 1992. Stone RA, Yeo TC, Barnes PJ, and Chung KF. Frusemdie inhibits cough but not bronchoconstriction to prostaglandin in patients with asthma Abstract ; . Rev Respir Dis 143: A548, 1991. 25. Tanigaki T, Kondo T, Hayashi Y, Katoh H, Kamio K, Urano T, and Ohta Y. Rapid response to inhaled frusemide in severe acute asthma with hypercapnia. Respiration 64: 108110, 1997. Trout L, Gatzy JT, and Ballard ST. Acetylcholine-induced liquid secretion by bronchial epithelium: role of Cl and HCO3 transport. J Physiol Lung Cell Mol Physiol 275: L1095 L1099, 1998. 27. Widdicombe JH, Nathanson IT, and Highland E. Effects of "loop" diuretics on ion transport by dog tracheal epithelium. J Physiol Cell Physiol 245: C388C396, 1983 and quinapril. The following students have been awarded the diploma in clinical pharmacy community ; by the school of pharmacy, University of Bradford: Lisa Collins distinction ; , Daniela Cousins merit ; , Peter Gibbs merit ; , Alex Haddy distinction ; , Osama Madlom, Christine Nandudu, Karine Nash merit ; , Susan Regan merit ; , Elizabeth Scott distinction ; , Donnella Smith distinction ; , Nicola Stanbridge, Deborah Wootton distinction ; . The following candidates have been awarded the certificate in clinical pharmacy community ; by the school of pharmacy, University of Bradford: Javed Iqbal, Oluranti Oluwatimehin.
Tumor suppressor and motility functions of p16INK4A growth arrest in normal and premalignant epidermis and oral epithelium E Natarajan, 1, 5 M Saeb, 2 JD Omobono, 1 SB Woo, 3, 5 PH McKee2, 4 and JG Rheinwald1, 4 1 Dermatology, Brigham and Women s Hospital, Boston, MA, 2 Pathology, Brigham and Women s Hospital, Boston, MA, 3 Oral Medicine and Diagnostic Sciences, Brigham and Women s Hospital, Boston, MA, 4 Harvard Medical School, Boston, MA and 5 Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA A high frequency of mutation, deletion, and promoter silencing of the p16INK4A p16 ; gene in premalignant dysplasias and squamous cell carcinomas SCC ; of epidermis and oral epithelium has identified p16 as a tumor suppressor. The point during neoplastic progression at which p16 is expressed and impedes formation of an SCC has remained unknown. Upregulation of p16 expression has been found to cause senescence arrest and to limit the lifespan of normal human keratinocytes in culture, suggesting the possibility that excessive or spatially abnormal cell growth in vivo may trigger p16 expression. We examined 77 archival epidermal and oral mucosal biopsy specimens to test three increasingly focused hypotheses about the setting in vivo in which p16 expression occurs. We found that p16 expression does not result from chronic hyperproliferation but does occur heterogeneously in cells of dysplastic and carcinoma in situ CIS ; lesions, most consistently by cells at the invasive fronts of early SCCs. Such cells coexpressed p16 and laminin 5 gamma 2 lam5g2 ; , the latter identified previously by others as a marker of early invasion in carcinomas. Cells in normal keratinocyte cultures also coordinately upregulated p16 and lam5g2, associated with increased motility. Keratinocytes at the edges of experimental wounds made in confluent cultures also upregulated p16 and lam5g2, accompanying migration to fill the wound. Some cell lines that were p16-deficient or engineered to resist p16 arrest secreted lam5g2 and were motile. Thus, p16 expression does not cause but, rather, is induced coordinately with lam5g2. These results identify the point at which p16 acts as a tumor suppressor in vivo and suggest that normal keratinocytes may use the same mechanism to generate non-proliferative, motile cells for wound repair and aceon and frusemide, for example, pregnancy.
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