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1. Headache Research Methodology: Introduction to the S pecial S eries Penzien ; 2. Why Physicians S hould Pay Attention to Behavioral Research Maizels ; 3. S tatistical Power and S ample S ize Estimation for Headache Research: An Overview and Power Calculation Tools Houle, Penzien, Houle ; 4. Allocation of Patients to Conditions in Headache Clinical Trials: Randomization, S tratification, and Treatment Matching Lipchik, Nicholson, Penzien ; 5. Outcome Measurement Issues in Headache Research: Headache Parameters and Relevant Psychosocial Outcomes Andrasik, Lipchik, McCrory, Wittrock ; 6. The Assessment of Headache Activity Using Time-S eries Research Designs Houle, Remble, Houle ; 7. Time-S eries Features of Headache: Individual Distributions, Temporal Patterns, and Predictability of Pain Houle, Penzien, Rains ; 8. Methodological Issues in S ystematic Reviews of Headache Trials: Adapting Historical Diagnostic Classifications and Outcome Measures to Present Day S tandards McCrory, Gray, Tfelt-Hansen, S teiner, Taylor ; 9. Behavioral Headache Research: Methodologic Considerations and Research Design Alternatives Hursey, Rains, Penzien, Nash, Nicholson ; 10. Behavioral Research and the Double-Blind Placebo-Controlled Methodology: Challenges in Applying the Biomedical S tandard to Behavioral Headache Research Rains, Penzien ; 11. Methodological Issues in Clinical Trials of Drug and Behavior Therapies Holroyd, Powers, Andrasik ; 12. Headache and Psychiatric Comorbidity: Historical Context, Clinical Implications, and Research Relevance Lake, Rains, Penzien, Lipchik ; 13. Efficacy and Effectiveness Approaches in Behavioral Treatment Trials Nash, McCrory, Nicholson, Andrasik ; 14. Moderators and Mediators of Behavioral Intervention for Headache Nicholson, Hursey, Nash ; 15. Methodological Considerations in Research with S pecial Populations: Children and Adolescents Andrasik, Powers, McGrath ; 16. Future Directions in Behavioral Headache Research: Applications for an Evolving Healthcare Environment Penzien, Rains, Lipchik, Nicholson, Lake, Hursey ; 17. Editorial Lipton ; Andrasik-Science Forum-4 21 05 39.
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There are two drug classes in the United States: prescription and nonprescription. Nonprescription drugs may be sold in any retail outlet. Prescription drugs may be dispensed pursuant to a "practitioner's" order, usually a doctor's prescription. There are several exceptions to this. First, in Florida, some prescription drugs may be dispensed by pharmacists, who are considered "practitioners" under Florida law. See appendix V. ; Second, insulin is available in some states without a prescription but only from pharmacists. Third, in some states some controlled substances may be dispensed by a pharmacist without a prescription if there is low abuse potential. Fourth, there are some situations in which pharmacists have dependent prescribing authority. Typically, in this situation, pharmacists may prescribe drugs but only under protocols established by supervisory physicians. See chapter 5 for more discussion on these four cases and anastrozole. 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O11 Analyses of Plant Hormones using Capillary Electrophoresis-tandem Mass Spectrometry Liya Ge, Jean Wan Hong Yong, Swee Ngin Tan Natural Sciences and Science Education Academic Group Nanyang Technological University Capillary electrophoresis CE ; coupled to mass spectrometry MS ; or tandem mass spectrometry MS MS ; is reported for the first time as an alternative and powerful analytical method for the separation and determination of plant hormones, including indole-3-acetic acid, indole-3-butyric acid, abscisic acid, gibberellic acid, zeatin, N6-benzyladenine, a-naphthaleneacetic acid and 2, 4-dichlorophenoxyacetic acid. The success of using the CE-MS MS approach was attributed to the electroosmotic flow reversal using a cationic polymer-coated capillary. The various parameters for CE-MS MS optimization, such as buffer pH, concentration of buffer and organic modifier, applied voltage and sheath liquid were evaluated systematically. Under optimum conditions, a baseline separation of eight plant hormones was accomplished within half an hour. The accessibility of MS or negative ion mode ; results together with the characterization of migration properties obtained by CE qualify CE-MS as a powerful method for the analysis of endogenous plant hormones. Compared with the other analytical techniques, the current developed CEMS MS method has several advantages: i ; various types of plant hormones, which are present as anionic forms could be separated and analyzed without derivatization in a short analytical time; ii ; relatively high sensitivity were achieved; and iii ; plant hormones could be selectively determined without serious matrix interference. Furthermore, the present methodology provides high resolving power, excellent reproducibility and low sample consumption. The utility of the CE-MS MS method was demonstrated by the comprehensive analysis of plant hormones in coconut Cocos nucifera L. ; water after preconcentration and purification through solid-phase extraction cartridges. It is also expected that the method could be applied to the analysis of plant hormones in a wide range of biological samples and arava. Becton Dickinson & Co. manufactures medical devices & diagnostics ; Univ of Minnesota Med School Christiana Care Health System Cincinnati Children's Hospital Medical Ctr.

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