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Zyban side effects treatmentReferences 1. Hbert S. Bupropion Zyban, sustained-release tablets ; : reported adverse reactions. Can Adverse Drug Reaction Newsl 1999; 9 2 ; : 1-2. [Also in CMAJ 1999; 160 7 ; : 1050-1.] 2. Zyban, bupropion hydrochloride; 150mg sustained-release tablets: smoking cessation aid [product monograph]. Mississauga ON ; : Glaxo Wellcome Inc.; 1999 Aug 19. Agreement with the findings of El-Shaboury.18 It is also clear from the tables that all the tablets exhibited good mechanical properties with regard to both hardness and friability. Nonsignificant differences in hardness values within each of the drug formulations were observed, while the friability decreased as the concentration of -CD increased. Tablets containing 100% -CD displayed the lowest value of friability for wet granulation and direct compression. 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