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Conclusions: typical plasma lidocaine concentrations observed during epidural anesthesia are unlikely to prevent the use of pupillary responses to evaluate sensory block level.
Proposed membership The membership will include representation from: Chair - GP or hospital consultant 1 ; Secretary - primary or secondary care pharmacist 1 ; General practitioners 2 from pool of 4 ; Hospital consultants 2 from pool of 4, spanning all care groups if possible ; Non-medical prescriber 1 ; PCT pharmacist 1 ; Hospital pharmacist 1 ; PCT HCT finance representative 1 or 2 ; The chair and secretary will be elected every two years, with members elected every three years consultants by HMSC, GPs by PCPC ; . Any proposed additional membership will be considered by the committee for inclusion, unless jointly required by the HCT or PCT executive committees. Members who have not attended at least 4 meetings annually will be requested to find an alternative representative from their area of practice. If this is not done within 2 months, a request will go to the relevant electing body to obtain a recommendation. Decision making Decisions are to be made by consensus. However, if clear differences of opinion prevail, decisions may be made at the discretion of the chair, by committee members vote. Proposers or other attendees may not vote. Decisions which are anticipated to have a net health economy drug cost of up to 30, 000 annum may be made by the committee without referral. Such decisions must be mindful of the overall drug budget for the locality, and may be subject to a total annual 'budget' allowance. Decisions which exceed this threshold must be taken as recommendations to the HCT operational board and PCT PEC for approval. A joint review of the threshold amount will be undertaken annually by the executive teams. Probity All proposers must include a declaration of interest on their formulary submission document. All employees of either the HCT or PCT are subject to organisational requirements on declarations of interest. In addition, all committee members and proposers attending each committee must sign the 'Declarations of interest' register at the meeting. This is to verify that committee members have no interests in the decisions being made, and that proposers have had no material changes since their original declaration. All sponsorship of meetings for catering, venues etc. will be formally recognised in committee documentation and hence transparent to audit, because mequinol tretinoin.
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Compliance with the principles of healthy eating An analysis of the findings of this survey allows the number of women whose nutrition does not comply with the principles of healthy nutrition to be determined Figure 23 ; . Figure 23. The number of women whose nutrition does not comply with the principles of healthy eating.

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Trachoma, tetracyclines for, 1177 TRACRIUM atracurium ; , 222t TRACTOTILE atosiban ; , 1507 "Train of four" stimulus schedule, 229 Tramadol, 566, 580t pharmacokinetics of, 1880t1881t TRANDATE labetalol ; , 852 Trandolapril, 802f, 803 absorption and elimination of, 803 adverse effects of, 808810 dosage of, 803 in heart disease, 806t807t for hypertension, 858859 therapeutic uses of, 804808 Tranilast, in Gilbert's syndrome, 81 Transdermal opioids, 582583 TRANSDERM SCOP scopolamine ; , 197, 1004 Transducer s ; , 2425 Transducin, 1732 Transduction, and drug resistance, 1098 Transferrin, 1443 Transfersomes, 1681 Transformation, and drug resistance, 1098 Transforming growth factor- cyclosporine and, 1409 in inflammation, 672 Transient receptor potential TRP ; ion channels, 322 Transplantation ganciclovir and, 1255 general approach to, 1406 rejection of prevention of corticosteroids for, 1610 cyclophosphamide for, 1328 immunosuppression for, 14061407 sargramostim for, 1439 tolerance and, 14201421 Transport, of drugs across membranes, 13 active, 3, 45f, 4647 primary, 45f, 46 secondary, 45f, 4647 basic mechanisms of, 4547 energy-dependent phase I and II, 1156 inhibition of, 47 and drug interactions, 122 kinetics of, 47 passive, 2, 4546, 45f pH influence on, 3, 3f physiochemical factors in, 13 rate of, 47 saturation in, 18 vectorial, 4748, 48f, 58 Transporter s ; , 4167. See also specific types in adverse drug responses, 42f, 4345, 44f versus channels, 45, 45f in clearance organs, 43, 44f and drug-metabolizing enzymes, 41, 42f in drug resistance, 43, 1097 as drug targets, 4143 for endogenous ligands, 4445, 44f expression of, regulation of, 48 functions of, 41 genetic variation in, 5758 in kidney, 43, 44f, 48, in liver, 43, 44f, 48, and uptake, 5960 molecular structures of, 4952, 50f for neurotransmitters, 4142, 6566 nonneuronal, 4243 in pharmacodynamics, 4143 in pharmacokinetics, 41, 42f, 5867, superfamilies, in human genome, 5157 in therapeutic drug responses, 4143, 42f in toxicological target organs, 4345, 44f uptake and efflux, 58, 59f Transposons, 1098 Transthyretin, 1516 TRANXENE clorazepate ; , 410t Tranylcypromine, 437t, 439 for depression, 432 dose and dosage forms of, 437t mechanism of action, 175 for Parkinson's disease, 535 physical dependence on, 447 side effects of, 437t Trastuzumab, 1374, 13761377 infusion reaction to, treatment of, 570 mechanism of action, 1377t, 1378 pharmacokinetics of, 1378 pretreatment testing of, 1321 therapeutic use of, 1377t, 1378 TRASYLOL aprotinin ; , 648 TRAVATAN travoprost ; , 1722 Traveler's diarrhea loperamide for, 997 quinolones for, 1121 Travoprost, for glaucoma, 17221723 Trazodone, 311, 437t CYP interactions of, 445t, 446 dose and dosage forms of, 437t drug interactions of, 450 for insomnia, 423 mechanism of action, 443 metabolism of, 444 pharmacokinetics of, 445t, 446, 1881t potency of for receptors, 440t for transporters, 438t side effects of, 437t, 447448 TRECATOR-SC ethionamide ; , 1212 TRELSTAR triptorelin ; , 1387, 1502t Trematodes, 1073, 1078 Tremor s ; , adrenergic receptor agonists and, 253 Trench mouth, penicillin G for, 1137 Tretinoin, 1315, 1366, 16831684, for acne, 1684 chemistry of, 1731, 1732f clinical pharmacology of, 13651366 therapeutic uses of, 1684 toxicity of, 1366 TREXALL methotrexate ; , 1338 Triamcinolone, 1594t, 1597f, 1603 for asthma, 721722, 16081609 for rhinitis, 731 topical preparations of, 1682t, 1683 and retrovir.

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