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Share paid-in capital 1 ; Argentina Novartis Argentina S.A., Buenos Aires . Australia Novartis Australia Pty Ltd., North Ryde, NSW . Novartis Pharmaceuticals Australia Pty Ltd., North Ryde, NSW Novartis Consumer Health Australasia Pty Ltd., Mulgrave, Victoria . Novartis Animal Health Australasia Pty Ltd., North Ryde, NSW Austria Novartis Pharma GmbH, Vienna . Novartis Forschungsinstitut GmbH, Vienna Sandoz GmbH, Vienna . Sandoz GmbH, Kundl . Novartis Animal Health GmbH, Kundl . ARS AUD AUD AUD AUD EUR EUR EUR EUR EUR BDT EUR EUR EUR EUR CHF CHF CHF BRL BRL CAD CAD CAD CLP 230.6 m 11.0 m 3.8 m 7.6 m 3.0 m 1.1 m 10.9 m 100, 000 32.7 m 37, 000 162.5 m 7.5 m 7.1 m 4.8 m 62, 000 1.0 m 30, 000 10.0 m 158.1 m 19.9 m 1.3 m 2 1 2.0 bn Equity Interest % 100 Activities v and prozac. Next in thread: mary: procardia nifedipine reply: mary: procardia nifedipine reply: sierra: procardia nifedipine reply: samir fouad aziz md: procardia nifedipine i stumbled upon a post here questioning procardia usage during pregnancy. Found to be equivalent to risk factors such as dyslipidemia, hypertension, smoking status, and diabetes.4 Several postulated mechanisms of action relating subclinical hypothyroidism to atherosclerosis include the effect of thyroid hormone on coagulation and vasodilation, hypofunctioning of the parasympathetic nervous system, and increased homocystine levels.4, 6 The prevalence of subclinical hypothyroidism is 421% in women and 316% in men, 3 with more than 10 million people affected in the United States and approximately 43 million in Europe.3 Based on the Colorado Thyroid Health Survey3 conducted in 1995, the incidence of hypothyroidism increases with age. The data showed that the incidence was 21% in women older than 74 years compared to 4% in women aged 1824 years.3 The prevalence of thyroid disease in patients with diabetes is significantly higher than that in the general population. It has been reported as 13.4%, with the highest in patients with type 1 diabetes 31.4% ; and lowest in patients with type 2 diabetes 6.8% ; .7 In addition to the autoimmune link between type 1 diabetes and thyroid disease, diabetes and thyroid disease are more commonly found in the elderly, further contributing to the high association.8 Thyroid function should be evaluated yearly in patients with diabetes. An outpatient diabetes clinic in Scotland randomly screened 1, 310 adult patients with diabetes for thyroid disease. The prevalence of thyroid disease was found to be 13.4%, of which 6.8% were diagnosed during the screening. The remainder had previously known disease. The most common thyroid dysfunction was subclinical hypothyroidism 4.8% ; .7 Symptoms of subclinical hypothyroidism are particularly insidious and often overshadowed by coexisting health problems, or the symptoms are attributed to aging. Symptoms include dry skin, poor memory, slow thinking, weak muscles, muscle cramps, feeling cold, puffy eyes, constipation, hoarse voice, and deep voice.3 Unfortunately, these symptoms are also found frequently in people without thyroid disease. According to the Colorado Thyroid Health Survey and psilocybin.

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Regarding the separation of migraine without aura and tension-type headache, investigators should consult the IHS criteria 33 ; . 2.1.2 Other non-migranous ; headaches Recommendations: Other headaches are permitted if the patient can clearly differentiate them from migraine by the quality of pain one-sided, pulsating, moderate or severe intensity ; and or by the prole of associated symptoms i.e. nausea, discomfort to light or sound, visual symptoms or other aura ; . Early safety and efcacy studies should exclude other headache. Comments: Many patients with migraine have socalled interval headaches which do not meet IHS criteria for migraine Cephalalgia 1988; 8 Suppl 7 ; : 196 ; . Future studies may show that interval headaches are indeed fragments of migraine without aura but, for the present, patients who cannot distinguish interval or other nonmigrainous headaches from typical migraine without aura must be excluded. 2.1.3 Frequency of attacks Recommendations: Attacks of migraine should occur 26 times per month. The frequency of other headaches should be no more than 6 days per month. There should be at least 48 h of freedom from headache between attacks of migraine. Comments: The numbers in this section are to some extent arbitrarily derived, but it is important that prophylaxis is clinically indicated in patients who enter prophylactic trials. The recommended frequency of 26 attacks per month allows for more rigid standards in certain trials. Other including interval ; headaches of more than 6 days per month would begin to blend into attacks of migraine without aura if migraine were to occur as often as 6 days per month. Patients may identify relapse or recurrence within 48 h of effective acute treatment as a new attack. Forty-eight hours of freedom between attacks of migraine permits identication of individual attacks and distinction from relapse recurrence ; . 2.1.4 Duration of disease Recommendations: Migraine should have been present for at least 1 year. Comments: Because there are no objective signs of migraine, a minimum course of 1 year is advisable to help exclude headaches due to organic disease that may mimic migraine, and to establish a stereotyped pattern for the patient's headaches.

Ss Who Needs XR, LA, SR, XL, ER, or CR? Most managed care pharmacists have quipped at one time or another that SR sustained release ; at the end of a drug name stands for sustained revenue, ER extended release ; really means extended revenue, and CR controlled release ; really means continued revenue. In this issue of JMCP, Hong et al. applied logistic regression analysis to the prices of 27 drugs that lost patent protection and concluded that price rigidity was more likely to occur in brands with product-line extensions such as SR, ER, LA [long-acting], etc. ; compared with brands without extensions.1 Hong et al. raise the obvious point about public policy surrounding a business practice that contributes to rising prescription drug expenditures. The authors cite, for example, Cardizem CD diltiazem ; , which earned more than $735 million in community pharmacy sales during the 12 months ended May 1999, and Procarda XL nifedipine, extended release ; , with sales of $299.7 million during the 12 months ended October 2000, combined pharmacy sales of more than $1 billion per year despite the fact that generic versions of the these 2 drugs had been available for 8 to 10 years in the immediate-release IR ; dose form. Is there a clinical argument, beyond the convenience associated with the use of fewer doses per day, that might provide support for price rigidity and sales revenue expansion attained through product extension via SR dose forms? Researchers at the Wake Forest University School of Medicine reported in 1995 that short-acting calcium channel blockers CCBs ; caused more harm than benefit in patients, and followed that report with results of a meta-analysis of 9 randomized controlled trials presented in August 2000 that showed a 27% higher risk of heart attack and a 26% higher risk of heart failure in patients on all including LA ; CCBs versus alternative therapies diuretics, angiotensin-converting enzyme inhibitors [ACEIs], beta-blockers ; for hypertension: diuretics, ACEIs, or beta-blockers.2 And, according to the combined results of 42 clinical trials involving 192, 478 patients, low-dose diuretics are the most effective first-line treatment for preventing the occurrence of cardiovascular disease morbidity and mortality. Compared with CCBs, low-dose diuretics were found to be associated with reduced risks of cardiovascular disease events relative risk [RR], 0.94; 95% confidence interval [CI], 0.89-1.00 ; and congestive heart failure RR, 0.74; 95% CI, 0.67-0.81 ; .3 So, it is not clear whether LA CCBs are any safer than short-acting CCBs, but they are more expensive in direct drug cost and are not first-line therapy for hypertension. This matter of product line ; revenue extension is significant in the U.S. pharmaceutical market. For pharmacy claims with dates of service in 2005 in the third quarter ended September 30 2005 Q3 ; , venlafaxine XR extended release ; was ranked #4 in total expenditure for small employers, accounting for 1.7% of total drug benefit expenditures, surpassed in expenditure by only 3 drugs: atorvastatin, lansoprazole, and esomeprazole.4 and ritalin.
The average cost per prescription for all drugs prescribed to foster children in fiscal 2004 was $90.

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