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From the Division of Gastroenterology and Hepatology, Department of Medicine, Karl Franzens University, Graz, Austria M.T. the Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland P.J.M. and the Department of Medicine and Liver Center, Yale University School of Medicine, New Haven, Conn. J.L.B. ; . Address reprint requests to Dr. Boyer at the Yale University School of Medicine, P.O. Box 208109, New Haven, CT 06520-8019. 1998, Massachusetts Medical Society and ortho.
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A comprehensive search was made of MEDLINE 19661999 ; , EMBASE 1980 to 1999 ; and International Pharmaceutical Abstracts 1970 to 1999 ; , unrestricted as to language. We sought prospective or retrospective studies investigating ADRs. These included patients who were admitted to hospital as the result of an ADR and or experienced an ADR during an inpatient stay. Search terms included "adverse drug" or "adverse reaction", "iatrogenic", "drug-related" or "drug-induced" and "hospital". We also examined reference lists of reviews and retrieved reports. Studies were sought with the following designs.
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