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Some of the most commonly experienced early complications in multiple traumas have been placed together in a single category, T79--Certain early complications of traumas, not elsewhere classified. When a trauma complication, such as a hemorrhage or infection, follows medical surgical procedures intended to repair the injured site, select the appropriate code from the range of categories T80 to T88 "Complications of surgical and medical care, not elsewhere classified". Exception: In a patient with multiple traumas, shock may be assumed to be due to the trauma assign code T79.4--Traumatic shock ; unless the physician clearly states another cause--for example, shock due to anaesthetic code to T88.2--Shock due to anesthesia.
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An assessment of Existing Wastewater Treatment Works was carried out in July 2002 and is included in Appendix E of this report. The assessment considered site constraints relating to future expansion of the existing Works within the study area, and these are summarised in Table 8.5 below. WwTW Ringsend Shanganagh Bray Osberstown Leixlip Portrane Malahide Balbriggan and Skerries Swords Table 8.5 Site Constraint 0.8 ha available 1.08 ha available 1.36 ha within existing site Further land available Further land available No land available Further land available Limited land available. Site Constraints Comments Land availability is a major constraint on future development. Land available for ultimate design. Receiving water major constraint on future development. Receiving water major constraint on future development. No further constraints identified. Limited scope for expansion. May need further land for extension to ultimate design depending on proposed process. Receiving water constraint on future development.
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LEGAL PROCEEDINGS Reference is made to the "Legal Proceedings" section in Teva's Annual Report on Form 20-F for the year ended December 31, 2003 and Teva's reports on Form 6-K with respect to the quarters ended March 30, 2004 and June 30, 2004. On September 14, 2001, Purdue Pharma L.P. "Purdue" ; filed an action in the U.S. District Court for the Southern District of New York, alleging that the filing of Teva Pharmaceuticals USA, Inc.'s "Teva USA" ; ANDA for 80 mg oxycodone hydrochloride extended-release tablets infringed three patents listed in the Orange Book for Purdue's OxyContin. Subsequently, on April 3, 2003, Purdue sued Teva USA on its 10, 20 and 40 mg tablet products. On January 5, 2004, those three patents were held unenforceable in a related case, Purdue Pharma L.P. v. ENDO Pharmaceuticals Inc., pending before the same judge as in Teva USA's case. Purdue has appealed that decision and oral argument was heard on November 3, 2004 before the Court of Appeals for the Federal Circuit. On June 25, 2004, Teva's motion for summary judgment was granted on the ground that collateral estoppel applied to the inequitable conduct finding in the ENDO case. On March 30, 2004, Teva USA commenced sales of its 80 mg tablets based upon the court's decision in the ENDO case. The 2003 annual sales of the branded product in the U.S. were estimated to be approximately $707 million. Were Purdue to be successful on its appeal, and if Teva USA does not receive a favorable decision in its own case, Teva USA could ultimately be required to pay damages related to the sales of 80 mg oxycodone hydrochloride extended-release tablets and be enjoined from selling this product. No provision for this matter has been included in the accounts. On September 12, 2002, Teva USA obtained summary judgment from the U.S. District Court for the Northern District of Illinois regarding a U.S. patent on a combination of Hydrocodone Bitartrate and Ibuprofen. The District Court ruled that the U.S. patent was invalid as obvious. Subsequently, on May 19, 2004, the Court of Appeals for the Federal Circuit reversed, mainly on procedural grounds, the District Court's summary judgment ruling of invalidity, remanding the case for further proceedings on the issues of infringement, validity and unenforceability. Trial has been scheduled for June 6, 2005. The patent expires on December 18, 2004. The patent was asserted by Knoll Pharmaceutical Company, now a subsidiary of Abbott Laboratories, which markets the combination as Vicoprofen. In April 2003, following FDA approval, Teva USA launched its product, Hydrocodone Bitartrate and Ibuprofen Tablets, 7.5 mg 200 mg. Annual sales in 2002 of the branded product in the U.S. were estimated to be approximately $ 108 million. Were Knoll Pharmaceutical Company to be successful on its allegation of patent infringement, Teva USA could ultimately be required to pay damages related to the sales of Teva USA's Hydrocodone Bitartrate and Ibuprofen tablets. No provision for this matter has been included in the accounts. On April 21, 2004, Rhodes Technologies and Napp Technologies "Rhodes Napp" ; filed a complaint in Massachusetts Superior Court, seeking an equal share of the value to Teva of the settlement of certain claims between GlaxoSmithKline and Teva relating to Teva's nabumetone products. The allegations are based upon the termination of a nabumetone API supply agreement between Teva and Rhodes Napp. No provision for this matter has been included in the accounts. The Company originally assessed the value of the product rights received in connection with the settlement at $100 million and subsequently revised the value to $70 million based on certain impairment factors not related to this action. On September 16, 2002, Sicor launched its idarubicin hydrochloride injection product. On July 8, 2004, Pharmacia filed a complaint in the U.S. District Court for the District of Delaware against Sicor, alleging that its idarubicin hydrochloride injection product infringes a Pharmacia formulation patent. Trial is scheduled for June 12, 2006. Annual sales of the branded product in the U.S. prior to Sicor's launch were estimated to be $40 million. Were Pharmacia to be successful on its allegation of patent infringement, Sicor could ultimately be required to pay damages related to the sales of Sicor's idarubicin hydrochloride injections and be enjoined from selling that product. No provision for this matter has been included in the accounts. As previously disclosed in Teva's Form 20-F for the year ended December 31, 2003 and Teva's Form 6-K with respect to the quarter ended June 30, 2004, Teva USA commenced sales of its 7.5 mg and 15 mg Moexipril Hydrochloride Tablets in May 2003. Following the filing of Schwarz Pharma's motion for a preliminary injunction, on September 12, 2004, Teva entered into an agreement with Schwarz Pharma regarding its moexipril hydrochloride tablets. Under the terms of the agreement, Teva agreed to suspend all manufacturing and selling of its moexipril hydrochloride tablets pending the outcome of litigation between the two companies in the District Court or a court order. On October 25, 2004, the District Court heard oral arguments on Schwarz Pharma's motion that seeks to find the patent valid and enforceable in light of the trial decision in the related case involving Teva's ANDA for Quinapril Hydrochloride Tablets, Warner-Lambert Company v. Teva Pharmaceuticals USA, Civil Action No. 99-922 DRD ; . The trial decision in that related case is currently being appealed to the Court of Appeals for the Federal Circuit. On 26.
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EXECUTIVE SUMMARY. 1 Effects of Isolated Cannabinoids, 2 Risks Associated with Medical Use of Marijuana, 4 Use of Smoked Marijuana, 6.
To the Editor: Kober, et al. 1 ; describe active warming as a means of improving pulse oximetry signal quality in pre-hospital trauma patients. Another technique I have used extensively on hospitalized trauma patients with poor pulse oximetry signals is to perform a digital block on the digit occupied by the oximeter. It is a simple and relatively noninvasive procedure. Using a 1 in. 25 GA. needle, with 12 cc. of 1% lidocaine, make sure no epinephrine is in the lidocaine ; inject circumferentially around the base of the digit. This single digit sympathectomy instantly enhances the pulse oximetry signal, and lasts 30 45 minutes. During that interval, volume replacement, warming and other resuscitative measures have usually resolved the issue. The procedure is so simple, effective and safe, only 10 20 mg. lidocaine involved ; that perhaps paramedics should be taught and authorized to perform it under radio call direction of an ER when indicated. Clair S. Weenig, MD and orlistat.
Crawford WJ, Merritt JC. 1979. Effects of tetrahydrocannabinol on arterial and-intraocular hypertension. International Journal of Clinical Pharmacology and Biopharmacy 17: 191?196.
Heparin for, 1472 hypertension and, 845 leukotriene receptor antagonists for, 658 lipid-lowering therapy in, 945 non-ST-segment-elevation, nitrates for, 831 opioids for, 561 prevention of aspirin for, 841 clopidogrel for, 841 NSAIDs for, 685 propionic acid derivatives and, 699 renin-angiotensin system in, 789 thromboxanes and, 664 tirofiban for, 1483 Myocardial ischemia, 823842 angina pectoris with, 823. See also Angina pectoris epinephrine and, 246 hydralazine and, 861 pathophysiology of, 823824, 824f Myoclonic seizure, 501, 502t, 503, Myoglobin, iron content of, 1443, 1443t Myometrium, estrogen progesterone and, 15461547 Myopathy colchicine and, 708 fibric acid derivatives and, 958 statins and, 951952 steroid, 1599, 1604 Myotonia congenita, quinine for, 1038 Myristolated alanine-rich PKC-kinase substrate MARCKS ; , 486 MYTELASE ambenonium chloride ; , 212 Myxedema, 1512, 1523, 1525. See also Hypothyroidism treatment of, 1525 Nabumetone, 679t, 701702 versus aspirin, 679t N-acetylation, 8586, 87t N-acetylcysteine NAC ; for acetaminophen overdose, 694695 for nitrate tolerance, 881 N-acetyl-p-benzoquinone NAPQ1 ; , 83 N-acetyl procainamide, 912t, 926927 N-acetyltransferases NATs ; , 73, 78f, 8586 polymorphism of, 85, 105t rapid versus slow, 85 Na + -Cl-symport inhibitors, 753757 NAD + , in ethanol metabolism, 592593, 592f Nadolol, 274f, 278, 278t for variceal bleeding prevention, 292 NADPH-cytochrome P450 reductase, in estrogen synthesis, 1542 Nafadotride, 471 Nafarelin, 1502t Nafcillin, 1129t, 11381139 adverse effects of, 1143 antimicrobial activity of, 1130t, 1133 major properties of, 1129t pharmacological properties of, 11381139 for staphylococcal infections, 1136, 11381139 Naftidrofuryl, for claudication, 842 Naftifine, 1239, 1690 NAFTIN naftifine ; , 1239 Naja naja, nicotinic receptors in, 217 Na + -K + -2Cl--symport inhibitors, 749753. See also Loop diuretics Naked monoclonal antibodies, 13751378, 1376t Nalbuphine, 565t, 574575, 580t NALFON fenoprofen ; , 678t Nalidixic acid, 11191122 in breast-feeding, 1102 chemistry of, 1120f in children, 1122 hyperglycemic effects of, 1634t phototoxicity of, 1741 for urinary tract infections, 1121 Nalmefene for alcoholism, 603 chemistry of, 565t, 576 for cholestatic pruritus, 1701 pharmacokinetics of, 1852t Nalorphine, 565t, 576 effects of, 556557 receptor action and selectivity of, 552t Naloxonazine, receptor action and selectivity of, 552t Naloxone, 547, 552t, 564, effects of, 576577 for obesity, 577 for opioid dependence, 577578 for opioid toxicity, 560, 573574, 577 "overshoot" phenomenon with, 577 pharmacokinetics of, 577578, 1852t pharmacological properties of, 576578 physical dependence on, 577 receptor action and selectivity of, 552t therapeutic uses of, 578 tolerance to, 577 Naloxone benzoylhydrazone, receptor action and selectivity of, 552t Naltrexone, 551, 552t, 565t, absorption, fate, and excretion of, 577 578 for alcoholism, 578, 602603, 613614 effects of, 576577 for obesity, 577 for opioid dependence, 577578, 620 for opioid toxicity, 577578 pharmacological properties of, 576578 physical dependence on, 577 for prurigo, 1701 receptor action and selectivity of, 552t therapeutic uses of, 578 tolerance to, 577 Naltrindole, 551, 576 receptor action and selectivity of, 552t Name s ; , for drugs, 131 NAMENDA memantine ; , 539540 Nanophyetus salmincola, 1078 Naphazoline, 261, 261f ophthalmic use of, 1721t, 1725, 1734 NAPHCON naphazoline ; , 261 NAPROSYN naproxen ; , 678t and ovral.
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What's more, the perception of patient harm was based on the real world experience of these surgeons, 78% of whom indicated that the slow nature of FDA's approval process had specifically hindered their own ability to treat patients "at least once." This is more than five-times the 14% who claimed that FDA had never adversely affected their care of patients. More than half characterized the problem as one that affects them at least "some of the time." Surgeons who had been practicing for 8 years or less were more apt than those operating longer to report experiencing difficulty due to FDA's slow drug approval process and parlodel.
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