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Etiology. We have had cases in Santa Cruz County, where neisseria gonorrhoeae was isolated from the upper reproductive tract during laparoscopy, while specimens from the cervix were negative. Finally, initial review seems to indicate that the use of pcr as a DNA technology for the diagnosis of gonorrhea, is no longer recommended. There have been sufficient instances of false positives to warrant this recommendation. This is especially true in low prevalence populations. While we do not see much local gonorrhea testing via NAATS using pcr, it is incorporated as technology in the thin-prep Pap smear. We have seen results obtained via thin-prep. Please be aware that the potential exists for a false positive gonorrhea, especially if this is the only mechanism used for STD testing. The thin-prep Pap should not supplant conventional STD tests, which are ideally done via one of the nucleic acid amplification tests, or NAATS. Almost all of the nucleic acid amplification tests utilized in our county incorporate the TMA, LCR, or SDA technology, which are excellent for the diagnosis of gonorrhea. For questions or a written copy of guidelines: please call Sharon Crowley, STD Controller, 454-4482, or email Sharon.crowley health.co.santacruz. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Heart, Lung, and Blood Institute and femara. MISCELLANEOUS NOTICES -- Continued Canadian National Railway Company, document deposited . * Cologne Life Reinsurance Company, change of name . CSX Transportation, Inc., document deposited . DJJ Leasing Ltd., documents deposited. Entergy Power Marketing Corp., application to export electricity to the United States . Flex Leasing II, LLC and Flex Leasing Corporation, documents deposited. Gracie, Cameron Sr., wharf, moorings and slipway in MacNeils Cove, N.S HSBC Bank Canada and Republic National Bank of New York Canada ; , application for letters patent of amalgation. Maritimes & Northeast Pipeline Limited Partnership -- Maritimes & Northeast Pipeline Project -- Notice of proposed detailed route. PCS Sales USA ; , Inc., documents deposited. Pcheries R. Allard Inc., aquaculture site in Baie de Cascapdia, Que. Red Deer County, new bridge over Medicine River, Alta * Royale Belge, release of assets . SLX Canada Inc., document deposited. Union Pacific Railroad Company, documents deposited. Union Tank Car Company, documents deposited.

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2002 $m Net loss ; income as stated under Irish GAAP Adjustments to conform to U.S. GAAP: Pooling of interests accounting acquisition accounting for Dura Goodwill amortisation Goodwill impairment Pre-acquisition results of Dura Merger costs Fair value financing costs Purchase accounting Acquired IPR&D Impairment of goodwill acquired IP Amortisation of intangible assets Other Abelcet business goodwill ; Impairment of Myambutoll Accounting for derivatives Amortisation of acquired product rights and finance charges Revenue recognition--impact of SAB 101 Revenue recognition--write-off of related intangibles Non-consolidated subsidiaries Associate accounting Loss on disposal of investment in associate undertaking Stock option compensation expenses Pensions and other Net loss ; income before cumulative effect of accounting change as stated under U.S. GAAP Cumulative effect of accounting change net of tax ; Net loss ; income as stated under U.S. GAAP Basic loss ; earnings per Ordinary Share under U.S. GAAP before cumulative effect of accounting change Cumulative effect of accounting change Basic loss ; earnings per Ordinary Share under U.S. GAAP Diluted loss ; earnings per Ordinary Share under U.S. GAAP before cumulative effect of accounting change Cumulative effect of accounting change Diluted loss ; earnings per Ordinary Share under U.S. GAAP 3, 615.1 ; a ; 1 ; 68.9 854.9 - - a ; 2 ; b ; -- 249.6 45.0 -- 100.0 44.4 ; 4.4 ; 19.2 61.8 58.7 ; 3.8 ; -- 0.1 ; 2.2 -- 785.2 22.3 - - 44.4 3.8 34.6 -- 90.9 13.0 -- 0.5 ; 1.2 246.0 ; -- 7.3 1.0 - - 70.7 ; -- 38.9 -- 3.2 31.8 ; 0.9 55.2 -- 0.4 ; - - 9.6 -- 32.8 35.1 ; 2.7 ; 2001 restated ; $m 887.2 ; 2000 $m 342.1. Lipoxygenase isozymes-l and 2 with soybean seedling lipoxygenase. Arch Biochem Biophys 238: 476-483 Siedow JN, Girvin ME 1980 ; Alternative respiratory pathway. Its role in seed respiration and its inhibition by propyl gallate. Plant Physiol 65: 669-674 Sircar JC, Schwender CF, Johnson EA 1983 ; Soybean lipoxygenase inhibition by nonsteroidal antiinflamatory drugs. Prostaglandins 25: 393-396 Spilatro SR, Anderson JM 1989 ; Characterization of a sobean leaf protein that is related to the seed lectin and is increased with pod removal. Plant Physiol 90: 1387-1393 Staswick P 1988 ; Soybean vegetative storage protein structure and gene expression. Plant Physiol 87: 250-254 Staswick PE 1989 ; Developmental regulation and the influence of plant sinks on vegetative storage protein gene expression in soybean leaves. Plant Physiol 89: 309-315 Staswick PE 1989 ; Preferential loss of an abundant storage protein from soybean pods during seed development. Plant Physiol 90: 1252- 1255 Staswick PE 1990 ; Novel regulation ofvegetative storage protein genes. Plant Cell 2: 1-6 Streeter JG 1978 ; Effect of N starvation of soybean plants at various stages of growth on seed yield and N concentration of plant parts at maturity. Agron J 70: 74-76 Vick BA, Zimmerman DC 1984 ; The biosynthesis of jasmonic acid by several plant species. Plant Physiol 75: 458-461 Vick BA, Zimmerman DC 1986 ; Characterization of 12-oxophytodienoic acid reductase in corn. Plant Physiol 80: 202-205 Vick BA, Zimmerman DC 1987 ; Oxidative systems for the modification of fatty acids. In PK Stumph, EE Conn, eds, The Biochemistry of Plants, Lipids, Vol 9. Academic Press, New York, pp 53-90 Wittenbach VA 1983 ; Purification and characterization of a soybean leaf storage glycoprotein. Plant Physiol 73: 125-129 and tamsulosin!
The analysts at SES observe mainly the German technology titles and comment on the current developments at these companies. The companies under continuous observation are judged under several aspects. Firstly a rating on a multiple step scale is given for strategy as well as for the present valuation of the respective company. These two ratings combined supply our performance assessment compared to both, the respective industry and the respective index. Ratings and performance estimations generally have to be understood as relative judgements with a view of 6-12 months. The results of our assessment are shown in a table according to the one on the right side of this page. The main aspect of analysis is the assessment of the performance compared to the index. -Strategy 0 Valuation 0, for instance, retrobulbar.

At higher concentrations. Nucleic acids were indispensable for fertility; their omission permitted the growth to adult of the original inoculum; but no progeny were produced, although the adult female reniained alive up to three weeks. Adenylic acid is indispensable, not replaceable by guanylic acid, and seems to constitute the bulk of the nucleic acid requirement. Best results were obtained with a mixture of adenylic, guanylic, cytidylic acids, and thymidine at a 2 concentration Table III lower or higher concentrations were less effective. Supplementation with various amounts of uridylic acid improved neither growth nor fertility. Adenine could and florinef. BENTLEY PHARMACEUTICALS, INC. AND SUBSIDIARIES NOTES TO CONSOLIDATED FINANCIAL STATEMENTS Continued ; In order to support the Company's growth in Europe, management is adding additional capacity to its pharmaceutical products manufacturing facility through a series of improvements. During the year ended December 31, 2004, the Company invested approximately $6, 567, 000 renovating and expanding the Company's manufacturing and warehouse facilities and approximately $5, 197, 000 for related machinery and equipment. In April 2004, the Company purchased a Spanish manufacturing facility and related machinery, equipment and inventory used to manufacture active pharmaceutical ingredients, for approximately $3, 309, 000. The Company is manufacturing and marketing some of these products through its subsidiary, Bentley API. The 11, 000 square foot facility is currently FDA approved for one product, which the Company sells to several customers, including customers in the United States. Depreciation expense of approximately $630, 000, $368, 000 and $212, 000 has been charged to operations as a component of depreciation and amortization expense in the Consolidated Income Statements for the years ended December 31, 2004, 2003 and 2002, respectively. The Company has included depreciation totaling approximately $2, 124, 000, $1, 139, 000 and $569, 000 in cost of net product sales during the years ended December 31, 2004, 2003 and 2002, respectively. NOTE 6 DRUG LICENSES AND RELATED COSTS Drug licenses and related costs consist of the following.
Lopinavir ritonavir may affect the efficacy of the oral contraceptive pill and expert advice should be sought in the scenario where both npep and emergency contraception need to be simultaneously prescribed and fludrocortisone. It may be valuable to know the cyp2d6 metabolic capacity of such patients to avoid drug interactions, which depend on the metabolic phenotype. Does diet affect breast cancer risk? review ; . Holmes MD; Willett WC. Breast Cancer Research 6 4 ; : 170-178, 2004. 103 refs. ; The role of specific dietary factors in breast cancer causation is not completely resolved. Results from prospective studies do not support the concept that fat intake in middle life has a major relation to breast cancer risk. However, weight gain in middle life contributes substantially to breast cancer risk. Alcohol is the best established dietary risk factor, probably by increasing endogenous estrogen levels. Hypotheses relating diet during youth to risk decades later will be difficult to test. Nevertheless, available evidence is strong that breast cancer risk can be reduced by avoiding weight gain during adult years, and by limiting alcohol consumption and ofloxacin and myambutol, for instance, side effects. A. Affirmative Defenses 1. Equitable Estoppel The doctrine of equitable estoppel is an affirmative defense to a claim of patent infringement. A patentee will be estopped from enforcing a patent against an accused infringer where 1 ; the patentee - through misleading conduct or statements - represents to the accused infringer that no infringement suit will be filed, 2 ; the accused infringer relies on that representation, and 3 ; the accused infringer will be materially prejudiced if the patentee is allowed to proceed with its claim.2 This defense turns on whether the patentee makes deceptive statements that cause the accused infringer reasonably to believe that the patentee does not intend to enforce its patents, coupled with prejudice.3 Generally, silence will not result in an estoppel unless there is a clear duty to speak, or the patentee's continued silence reinforces the accused infringer's belief that the patentee acquiesces in the accused infringer's activities. In our example, Company B the accused infringer ; would appear to have a strong defense of equitable estoppel against Company A. Company B would argue that Company A should be estopped from enforcing its patent rights covering the standard against Company B because Company A not only misled the association when it failed to disclose that it owned several patents, but also led Company B, in light of the disclosure requirements of the code of practice, to believe that it could practice the standard without infringing intellectual property rights of Company A, the proponent of the standard. The adoption of the standard and Company B's compliance may support a finding of prejudice. The Company is the subject of an ongoing investigation by the SEC commenced on or about 12 February 2002, which the Company believes relates primarily to the issues raised in the litigation described above. We do not believe that it is feasible to predict or determine the final outcome of these actions or the investigation or to estimate the amounts or potential range of loss, if any, with respect to the resolution of the actions or the investigation. In addition, the timing of the final resolution of the actions and the investigation is uncertain. The possible outcome or resolution of the actions could require substantial payments by us. We believe that an adverse outcome with respect to the actions or the investigation could have a material adverse effect on our business, financial condition, results of operations and liquidity. In addition, these actions, the investigation and other events, such as the decline in price of our shares and the downgrade of our debt rating, have materially adversely affected our ability to access sources of external financing for our business. As a result, our ability to meet our longer-term liquidity requirements and capital needs could be materially adversely impacted, which could have a material adverse effect on our business, financial condition and results of operations. We face intense competition from new brand name products and from lower-cost generic products. The pharmaceutical industry is highly competitive. Our principal pharmaceutical competitors consist of major international companies, many of which are larger and have greater financial resources, technical staff, manufacturing, research and development and marketing capabilities than Elan. Other competitors consist of smaller research companies and generic drug manufacturers. A drug may be subject to competition from alternative therapies during the period of patent protection or regulatory exclusivity and, thereafter, it may be subject to further competition from generic products. Additionally, generic competitors can challenge existing patent protection or regulatory exclusivity. Generic competitors do not have to bear the same level of research and development and other expenses associated with bringing a new branded product to market. As a result, they can charge much less for a competing version of our product. Managed care organisations typically favor generics over brand name drugs, and governments encourage, or under some circumstances mandate, the use of generic products, thereby reducing the sales of branded products that are no longer patent protected. Governmental and other pressures toward the dispensing of generic products may rapidly and significantly reduce, or slow the growth in, the sales and profitability of certain of our products not protected by patents or regulatory exclusivity and may adversely affect our future results and financial condition. For example, generic forms of Ceclor CD and M6ambutol were approved by the FDA and launched in 2001, reducing the revenues and profitability of these products. As a result, in 2001 we incurred an impairment charge of $94.2 million for Ceclor CD and $44.4 million for Myambtuol arising on write-downs of the product intangibles for these products. In addition, Zanaflex is not currently protected by patents or regulatory exclusivity. In June 2002, Elan announced that Eon Labs, Inc. received FDA approval to market a generic alternative for the Zanaflex 4 mg dosage form. Approximately 75% of prescriptions written for Zanaflex are for the 4 mg dose. In 2001, product revenues from Zanaflex were $161.7 million. Arising from the approval of a generic alternative for Zanaflex, Elan expects a significant decline in the sales and profitability of this product. Additionally, competitor products, including generic competitors' products, to any of Elan's other products may become available. The launch of generic versions of Elan's products may materially adversely affect our business, financial condition and results of operations. Our competitive position depends, in part, upon our continuing ability to discover, acquire and develop innovative, cost-effective new products, as well as new indications and product improvements protected by patents and other intellectual property rights. We also compete on the basis of price and product differentiation and through our sales and marketing organisation that provides information to medical professionals and launches new products. If we fail to maintain our competitive position, our business, financial condition and results of operations may be materially adversely affected. We are subject to extensive government regulation, which may adversely affect our ability to bring new products to market and may affect our ability to manufacture and market our existing products. The pharmaceutical industry is subject globally to significant regulation by state, local, national and international governmental regulatory authorities. In the United States, the FDA regulates the design, development, testing, manufacturing, labelling, marketing and promotion and felodipine.

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