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Ple was 25 years S.D.: 4.32; range: 1840 years ; . Education level was high with 23 72% ; of the sample having completed high school and 7 22% ; having obtained a university degree. At the time of the survey, 22 69% ; were attending university. Seventeen participants 53% ; were full-time students, 6 19% ; combined studies with part-time jobs, 7 22% ; worked exclusively, and 2 6% ; were unemployed. 3.2. History of drug use other than salvia ; Except for two participants, all those in the study 93.7% ; had a drink containing alcohol weekly. The average number of alcoholic drinks per week among the drinkers was 3.13 S.D.: 2.69, range: 114 ; . More than four-fifths of the participants 84.4% ; were smokers, with a mean number of 14 cigarettes per day S.D.: 6.74, range: 125 ; . Except for one participant, all participants 96.9% ; consumed cannabis at least once a week. The average number of cannabis joints was 21.32 per week S.D.: 15.68, range: 270 ; . They also had wide experience with other drugs; ecstasy had been used by 88%, cocaine by 84%, amphetamines 69%, opiates 56%, benzodiazepines 36%, and GHB 9%. Ninety-four percent of the volunteers had at some time used a psychedelic hallucinogen, the most frequent being psilocybian mushrooms 78% of all participants ; , followed by LSD 63% ; , ketamine 34% ; , ayahuasca 28% ; , Amanita muscaria 13% ; , peyote 6.3% ; mescaline 3% ; and Datura stramonium 3% ; . Ten volunteers 31% ; reported having consumed "other psychedelics" not listed in the questionnaire. Specified were: 2C-B four volunteers ; , San Pedro one volunteer ; and Argyreia nervosa one volunteer ; . 3.3. History and pattern of use of salvia Participants appeared to have first experienced salvia only recently, with 88% having used it for the first time in the last year. The average number of times the drug was consumed was 2 range: 15 ; . The source of the salvia was a "smart shop" in 88% of the cases and in the remaining 12% it had been obtained from a friend, without further specifying the source. All participants had consumed salvia as an extract and three 9% ; had also used the leaves. Commercially available extracts usually consist of ground salvia leaves impregnated with salvia tincture, so that the final product may contain 5, 10 or 20 times the original salvinorin-A concentration. Regarding the preferred route of administration, 75% reported having smoked the extract, 22% reported combining sublingual and smoked administration and 3% one subject ; reporting smoking the leaves and the extract combined. As to the smoking technique, all volunteers reported using a bong or a pipe. No participant reported smoking it in the form of cigarrettes or mixing salvia with tobacco or marijuana. When asked about the psychotropic potency of salvia, 75% of the participants described the experience elicited by salvia from "intense" to "very intense" or "extremely intense", with only 19% as "moderate" and 6% describing it as "slight and metoprolol.
Immunosuppressants are used to control severe manifestations of allergic, autoimmune and transplant-related diseases. Some drugs have a diffuse effect on the immune system while others have specific targets. Drugs with diffuse effects are more likely to cause damaging adverse effects, but the effectiveness of the more specific drugs may be reduced if their action can be bypassed by alternative metabolic pathways. Treatment protocols therefore frequently use drug combinations to minimise adverse effects and to prevent resistance to treatment. Although protocols are essential to allow scientific evaluation, the clinician must be prepared to tailor treatment based on the ongoing assessment of drug effects, disease activity and the robustness of the individual patient.