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Lide impact at the Cretaceous Tertiary K-T ; extinction boundary Alvarez et al., 1980 ; led some to propose an impact scenario to explain most, if not all, significant extinction events in the Phanerozoic record Raup and Sepkoski, 1984; Raup, 1986 ; . This is in spite of the lack of large, age-constrained impact structures or obvious confirmed stratigraphic evidence of impact horizons that can be correlated positively with extinctions other than the end-Cretaceous Hallam and Wignall, 1997; Hallam, 1998; MacLeod, 1998 ; . Part of the problem in establishing or discarding an impact origin for biotic events other than the K-T boundary, however, simply may be the incompleteness of the rock record, as well as the fact that many extinction horizons are not as sharp as those at the K-T boundary Ryder, 1996 ; . According to the ``nuclear winter'' hypothesis of Alvarez et al. 1980 ; , dust loading of the atmosphere from impact ejecta caused global darkening and disruption of photosynthesis at the end of the Cretaceous. Calculations show that this mechanism should operate for all impacts that form structures larger than 50 km Toon et al., 1982; Grieve, 1998 ; , as ``atmospheric blowout'' above the impact site propels the ejected debris into the upper atmosphere Melosh, 1989 ; . The extent of dust loading of the atmosphere and the consequent failure of photosynthesis resulting from the K-T impact has been questioned by Pope 2002 ; . This author acknowledges, however, that impact production of sulfate aerosols from the target rocks Pope et al., 1997 ; , and of soot from global wildfires Wolbach et al., 1990 ; are still viable processes for global cooling, greatly increased atmospheric opacity and the consequent shutdown of photosynthesis. 5.3.2. Evidence in the stratigraphic record Diagnostic evidence of bolide impact in the stratigraphic record includes high-pressure 10 45 Gpa ; mineral polymorphs, such as stishovite and coesite, and microscopic shock-deformation features in quartz, feldspar, and zircons Chao et al., 1960; Shoemaker and Chao, 1961; Milton, 1977; Roddy and Davis, 1977; Stoffler, 1972 ; . Other suggested indicators of extraterrestrial impacts, some still controversial, include impact glass microtektites, tektites ; , microspherules, Ni-rich spinels, micro-diamonds, fullerenes, soot and iridium anomalies Wolbach et al., 1988; Rampino and Haggerty, 1996; Koeberl, 1998; Hough. Cordarone Cordarone Corodil Corodil Corodil Corodil Corodil Corodil Corodil Corodil Corodil Comp Corodil Comp Cosmofer Cosopt Cosopt Cosaar Plus Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Coversyl Comp. Coversyl Comp. Covinan Vet. Cozaad Ozaar Coaaar Cozxar Cozaaf Cozaar Comp. Cozaar Comp. Cozaar Comp. Forte Cozaar Comp. Forte Cozaar Startpakke Creon Creon Creon Forte Creon Forte Crestor Crestor Crestor.
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ISSUE FOUR: A behavioral test can be an efficient means of identifying a driver who is under the influence of drugs. Summary The DRC [Drug Recognition and Classification] system works and can be adapted to multiple jurisdictions. The ideal impairment test has not yet been developed, and it is clear that interindividual variability is high on these tests. Measures of involuntary action seem to be more robust than cognitive or motor skills. With appropriate training, police officers can become proficient in administering these tests. Unfortunately, most of the behavioral tests commonly used today were specifically developed for detecting alcohol use; perhaps they can be improved to detect drug use. It may well be that certain subsets of these tests are more effective for detecting drugs, or that new tests must be devised. Some tests may be redundant, or unnecessary to identify DUID. Recommendations for where we need to go from here: 1. More studies are needed on the sensitivity and specificity of each behavioral test parameter for the major drug categories. 2. An evidence-based best practice example could be established, that has good sensitivity for the major drugs, while remaining quick and easy to administer and effexor.
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Products. Teva USA manufactures and sells all types of generic pharmaceutical products in a variety of dosage forms, including tablets, capsules, ointments, creams, liquids, injectables and, through the acquisition of Ivax, inhalants. The four most significant products that Teva sold during 2006 under exclusivity in the U.S. were the generic versions of: Zocor simvastatin ; , the largest generic launch in history to date, Zoloft sertraline ; , Wellbutrin XL bupropion ; and Pravachol pravastatin ; . In addition, during 2006, Teva sold generic versions of the following branded products in the U.S. listed in the order of launch ; : DDAVP desmopressin acetate ; , Clozaril clozapine ; , Desferal deferoxamine mesylate ; , Zonegran zonisamide ; , Novantrone mitoxantrone ; , MiraLaxTM polyethylene glycol ; , Proscar finasteride ; , Mobic meloxicam ; , Effexor venlafaxine ; , Cipro ciprofloxacin ; , Depo-Medrol methylprednisolone acetate ; , Ditropan XL oxybutynin ; , and Zofran ondansetron ; . The FDA requires companies to submit abbreviated new drug applications "ANDAs" ; for approval to manufacture and market generic forms of brand-name drugs. In 2006, Teva USA received 28 final generic drug approvals and 15 tentative approvals. The 15 tentative approvals received were for generic equivalents of the following products: Depakote, Actos, AdenoScan, Aciphex, Zofran tablets and OD tablets ; , Sarafem, Protonix, Cozaar, Hyzaar, Lotrel, Risperdal, Avelox, FocalinTM and Wellbutrin XL 150 mg. ; . A "tentative approval" letter indicates that the FDA has substantially completed its review of an application and final approval is expected once the relevant patent expires, a court decision is reached or the 30-month stay lapses. Teva's potential for revenue growth from generic products in the United States is closely related to its pipeline of pending ANDAs with the FDA, as well as tentative approvals already granted. As of February 14, 2007, Teva had 162 product registrations awaiting FDA approval including some products through strategic partnerships ; , including 42 tentative approvals. Collectively, the brand-name versions of these 162 products had U.S. sales in 2006 exceeding $92 billion. Of these applications, 78 were "Paragraph IV" applications challenging patents of branded products. Teva believes it is the first to file on 45 of these applications, the branded versions of which had U.S. sales of more than $37 billion in 2006. Branded product market size is a commonly used measurement of the relative significance of a potential generic product. Generic equivalents of any given product are typically sold at prices below and in those instances where there are multiple generic producers of the same product, substantially below ; the branded price. In most instances, FDA approval is granted on the expiration of the underlying patents. However, companies are rewarded with a 180 day period of marketing exclusivity, as provided by law, for successfully challenging or circumventing these patents. As part of its strategy, Teva actively reviews pharmaceutical patents and seeks opportunities to challenge patents that it believes are either invalid or are not infringed by its generic version. In addition to the financial benefits of marketing exclusivity, Teva believes that these activities improve health care by allowing consumers quicker access to more affordable, high quality medications. In Canada, the Therapeutic Products Directorate of Health Canada requires companies to make an Abbreviated New Drug Submission in order to receive approval to manufacture and market generic pharmaceuticals. During 2006, Novopharm launched 15 generic equivalents of the following brand products: Amaryl, Casodex, Effexor XR its largest launch in history ; , Fludara, Imitrex DF, Lipidil Supra, Mirapex, Novatrone, Remeron RD, Risperidal, Serc, Tiazac, Zofran, Zofran Injectable and Zovirax. As of the end of 2006, Novopharm had applications for 55 products awaiting approval of the Therapeutic Products Directorate. Collectively, the brand-name versions of these products had Canadian sales in 2006 of approximately U.S. $2.8 billion. Collaborations. As part of its strategy to reach the market with generic versions as early as possible, Teva seeks to enter into alliances with partners to acquire rights to products it does not have and or to otherwise share development costs or litigation risks or resolve patent barriers to entry. In 1997, Teva and Biovail Corporation International, through subsidiaries, entered into a ten-year marketing and product development agreement that provided Teva with exclusive U.S. marketing rights for certain of 14. 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