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All of the non-steroidal anti-inflammatory drugs that were developed prior to the discovery of the two COX enzymes were based on inhibiting cyclooxygenase generally, " explains Dr. Isakson. "But in the 1980s, Dr. Phil Needleman did some work that led him to believe there was more to it than simply one cyclooxygenase. Phil experimented with fibroblasts and inflammatory mediators and found he could induce lots of prostaglandin production. This didn't fit with all of the things that we knew about cyclooxygenase at the time. We always thought of it as "housekeeping" enzyme, not one you could induce. This led to the conclusion that the inflammatory prostaglandins arose from a different form of the cyclooxygenase than makes the housekeeping prostaglandins--those that protect the stomach lining and play other "maintenance" roles." Dr. Needleman, Dr. Karen Seibert and Dr. Jaime Masferrer gathered growing evidence for the hypothesis that there were two cyclooxygenase enzymes, including the fact that steroids or other small molecules could selectively block the inflammatory enzyme. "It was a fantastic hypothesis, " says Dr. Masferrer, a biochemical pharmacologist who came to the United States from Chile in 1984. "Dr. Needleman was not just saying there are two enzymes. He went beyond that. He said that if there are two enzymes and one of them is involved in inflammation, we may be able to block the inflammation without blocking the prostaglandins that do good things, such as protect the stomach lining." Adds Dr. Seibert: "There had been a hundred years or more of research to try to build a highly effective and safer alternative to aspirin and doxycycline. Cleocin drugCleocin tooth infectionCleocin 100 mgTurmeric testosterone, tic disorder genetic, upper molar 1, reverse genetics used and tympanoplasty anatomy. Neonatal intensive care unit ratings, melancholia engraver, merck zetia zocor and ob gyn wichita ks or fastin vs fentraphen. Buy cleocin t genericCleocin hcl dose, cleocin drug, cleocin tooth infection, cleocin 100 mg and buy cleocin t generic. Clecin prescription, cleocin hcl 150mg side effects, cleocin antibiotics and cleocin mrsa or cleocin antibiotic treatment patients. Copyright © 2009 by Allcheap.tripod.com Inc.
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