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Another approach, not outlined in the FSMB Model Policy, follows the 4 outcome domains of importance when treating a patient with chronic pain TABLE 4 ; . These have become known as the 4 "A"s, ie, analgesia, activities of daily living, adverse effects, and aberrant drug-taking behavior.27 At each patient evaluation, the medical record should indicate that each of the 4 "A"s has been assessed and the presence or absence of specific signs, symptoms, or behaviors noted. When a change in therapy is warranted, the rationale based on the assessment should be documented and rosiglitazone. International Federation of Pharmaceutical Manufacturers & Associations IFPMA ; Chemin Louis-Dunant 15, P.O. Box 195, 1211 Geneva 20, Switzerland Tel: + 41-22-338 32 20 - Fax: + 41-22-338 32 99 E-mail: admin ifpma - IFPMA Web site: : ifpma. HER-1 and HER-2 Status in ER + and ER + PR- Tumors HER-1 and HER-2 was performed on only a portion of patients because testing for these molecular markers was not the routine standard of care for all patients when this database was gathered. ER + PR- tumors were three times more likely than ER + PR tumors to express HER-1 25% versus 8%, respectively; P .001 ; , and the levels of HER-1 in ER + PR- tumors median 40 fmol mg protein, range 1011 084 ; were nearly twice those in ER + tumors median 24 fmol mg of protein, range 104071; P .02 ; Table 2 ; . ER PR- tumors were also statistically significantly more likely to overexpress HER-2 21% for ER + PR- versus 14% for ER + PR .001 ; Table 2 ; . Both HER-1 and HER-2 are markers of tumor aggressiveness in breast and ovarian cancer cells 36 ; . Not surprisingly, therefore, tumors expressing either HER-2 or HER-1 were more likely to have a intermediate or high S-phase fractions than tumors negative for these two growth factors, regardless of PR status Table 3 ; . It interesting, however, that the differential in and irbesartan. Effective than placebo.12 However, in a second randomized, placebo-controlled, dose-response trial, both dosages of 1.6 g d and 2.4-g Asaxol daily were found to be more effective than placebo P .03 and P .003, respectively ; . However, the higher dose appeared to be more effective in inducing early stabilization of disease activity.13 Dose-toxicity response of the oral mesalamine formulations has not been demonstrated. In dose-ranging trials of mesalamine, the frequency of adverse effects AEs ; did not increase at higher doses.10, 12, 13 This is in contrast to therapy with sulfasalazine, where the high incidence of dose-related toxicity may preclude its use at higher doses.3, 14 The efficacy of higher doses of mesalamine in patients with moderately active disease but not mildly active disease ; has recently been confirmed in the Assessing Safety and Clinical Efficacy in a New Dose ASCEND I and II ; trials.15 In these multicenter, randomized, doubleblind, controlled trials, 687 patients with mildly or moderately active UC received delayed-release mesalamine 2.4 g d or 4.8 g d for 6 weeks, delivered in 400-mg and investigational 800-mg tablets, respectively.15 Although there was no difference in the efficacy of 2.4 g d and 4.8 g d in patients with mild disease, 4.8 g d was superior to 2.4 g d in the 423 analyzable patients with moderate UC P .05 ; Figure 2, page 4 ; .15 These studies also demonstrated consistent efficacy in moderately active patients across all extents of disease ie, proctitis, proctosigmoiditis, left-sided colitis, and pancolitis ; .16 As in previous dose-response studies, the frequency of AEs was not significantly different between the lower-dose and the higher-dose treatment groups, and both doses were well tolerated.15. 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