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Ctd. from p. 1 ; Ask them about how they celebrate and talk about the things that you and your family do. You might even want to visit your library to learn more about winter holidays other than your own; there are many great kids' books that talk about Christmas, Hanukkah, Kwanzaa, and more. There's no right or wrong way to celebrate the holidays. Families enjoy different traditions, or special things they do every year at the same time. Dreaming of Piles of Presents A sweater and socks again? Of course it's fun to dream about a special toy you want to get this December, but remember that you may not get what you ask for. The presents are not what winter holidays are about. People give you presents because they love you. If you don't get what you want, it's OK to feel a little bit sad about it, but you should always be happy and thankful that someone thought of you. You might feel upset when you rip off the wrapping paper and don't see your dream toy, but you have other chances to get the present you asked for. You can save your allowance to buy it for yourself or wait for your birthday. In the meantime, enjoy the presents you did get, remember that you may get what you wanted later on, and remember to thank the person who thought of you. If Your Family Isn't the Same as Last Year Maybe you've moved far away from family members, your parents are divorced or remarried, or someone close to you has passed away. The holidays can sometimes be a sad, stressful, or difficult time for those whose families aren't the same as they once were. Here are a few ways to make a new situation better. If your parents are divorced, you may spend the holiday in two or more places or you may not get to see both parents on the same day. You may be asked to share the holiday with one parent and his or her new boyfriend, girlfriend, husband, or wife. You may spend the holiday with new stepbrothers or stepsisters. If you feel unhappy or confused about the way you'll be spending the holiday, talk to your family about it. It's OK to be sad or upset, and you should tell your mom or dad or another adult you trust how you feel. It's also OK to have mixed-up feelings. The most important thing is to share those feelings and not keep them inside. It may help to ask your mom or dad exactly what the holiday plans are. This way, you'll know what to expect. If there's something you really want to do, like go to a party at your school, church, or temple, ask your mom or dad ahead of time if you can schedule that event as part of your day. Also, it's a good idea to plan a fun activity just for yourself. You could make a craft, read a book, or play with a new toy to keep from getting bored. If your family is different this year, start a new tradition. Make special cookies, dance to a special song, light a candle, or have everyone decide on something that will make the holiday special and memorable. The holidays can also be a time to remember the people we love who have died. It's OK to be sad about missing someone. It may make you feel better to do something in the person's honor, such as making him or her a card or small gift. Some families also find that sharing fun and nice memories of the person can help them feel better. Remember that no matter which part of your family you are with this holiday season, you are still important and loved by everyone. Keeping Your Holiday Cool If you've ever been shopping right before the winter holidays, you'll remember that the mall was crowded, the lines were long, and people were crabby. This kind of holiday stress could affect you, so try to keep your cool. Make sure you get plenty of sleep and exercise and don't eat too many sugary snacks and candy - a little bit is OK, but a lot will make you feel sick. Keep yourself in good health this holiday season to keep your stress low. Try not to worry about all the parties you hope to go to and the presents you hope to get. Just enjoy yourself and have a good time playing with friends and visiting family. Making gifts for the people you love is fun, and they will love getting presents as much as you do. Remember that holidays aren't about getting stuff; they're about spending time with people you love. Another nice holiday idea: give to charity or help those who have no family of their own. Tell your mom or dad that volunteering at a hospital or homeless shelter is a great way to share the holiday spirit and ask if you can make it a family activity. Whether you find the holidays super or stressful, remember that they'll be over in about a week or so. 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Coumadin cozaar, furosemide, hytrin, imdur, inderal, k-dur, lanoxin, laskx and naprosyn. We report 2 adults with a past history of radiation therapy to the head for malignancy one with primary B-cell lymphoma confined to the skull and the other with multiple hemangioendotheliomas ; who developed episodes consistent with migraine with and without aura. In addition to more typical migraine attacks and beginning many years after their radiation therapy, both patients have experienced infrequent, stereotyped, prolonged, reversible neurologic deficits associated with headache, occasional seizures, and striking, transient, cortical gadolinium enhancement of the posterior cerebral gyri on MRI. Interictal MRI brain scans show stable abnormalities consistent with the patients' previous radiation therapy. The neurologic deficits often progressed over a few days, sometimes lasted weeks, and completely resolved. Electroencephalograms did not show epileptiform activity. Thorough investigation showed no residual or recurrent tumor and no recognized cause for the patients' attacks. We postulate a causal relationship between the patients' remote radiation therapy and their prolonged, strokelike migraine attacks. Radiation-induced vascular changes could provoke the episodes, with or without an underlying migraine diathesis. Recognition of this syndrome can help avoid invasive testing. Neuro-Oncology 5, 121127, 2003 Posted to Neuro-Oncology [serial online], Doc. 02-040, February 24, 2003. URL : neurooncology .duke, for example, cheap lasix. FACULTY OF PHARMACY UNIVERSITY OF MANITOBA A Licensed Pharmacist is required to assist with the third year dispensing undergraduate lab course 46.346. Qualifications: Minimum 3 years community pharmacy experience, excellent communication skills, must be able to work with undergraduate students, must have a strong focus on patient care, patient counselling, and some knowledge of the applications of pharmaceutical care. Experience with A. Kroll or AH Computer System would be an asset. Hours: 8: 30 a.m. 4: 30 p.m. every Tuesday, commencing Tuesday, January 4, 2000 to Tuesday, March 21, 2000 Excluding Tuesday, February 15, 2000 ; . Salary: $26.50 Includes vacation pay at 6% ; Please send resume to: Mrs. S. Guenther, Faculty of Pharmacy, University of Manitoba, Winnipeg, MB. R3T 2N2 and nexium. Cheap order for chlorphenesin for oral dosage form tablets ; : for relaxing stiff, sore muscles: adults and teenagers-800 milligrams mg ; three times a day, at first. The semi-permeable wall of the tablet can contain at least one passageway communicating the contents of the core with the exterior of the device, delivering the beneficial drug through the passageways from the elementary osmotic device and phentermine. In summary, the FDA would like to encourage the pharmaceutical industry towards the responsible development and marketing of abuse-resistant products. Implicit claims resulting from valid studies potentially related to abuse such as extractability or euphoria ; can potentially be included in the product label, and in promotional materials; however the validity of such claims will require thorough review. Explicit claims are possible but the methodology will require much careful consideration, and the threshold for explicit claims will be much higher. In order to facilitate the process of achieving appropriate labeling claims, early collaboration with the FDA on a Target Product Profile is strongly encouraged. Assessment of Abuse Liability Benchtop testing. Tampering, or extractability, may be defined as "manipulating a pharmaceutical dosage form to change its drug delivery ; performance in a way not specified or intended by the manufacturer" from presentation by P. Goliber, PhD ; . Tampering is distinguished from abuse in that the latter can occur without manipulation of the dosage form. There are currently no industry standards for the evaluation of tampering extractability despite the effort of some groups. More work is urgently needed to develop industry standards around the testing and interpretation of tampering extractability, including issues around alcohol interactions. Abuse liability studies. Testing potentially addictive medications in clinical pharmacology studies has long been part of the evaluation of abuse liability. The goals of such studies are: to provide information for the label, to inform scheduling decisions, and to support public health. One study will not answer all questions due to diversity of patient populations, types of abuse, routes of administration, etc. The value of human abuse liability study results in the label includes: providing relevant information, helping define approved use, potential market advantages, and helping shape the risk management program. The phenomena that can be detected in such studies include: 1 ; aversive effects, 2 ; prodrugs, 3 ; antagonist effects, 4 ; dose-response of active, and perhaps of antagonist, 5 ; solubility and absorption. These studies are generally regarded as informative, and while there have been gradual refinements in the methods of abuse liability studies over the past several decades, these studies have important limitations. Further work is needed to promote the development of improved methods of abuse liability studies, particularly those relevant to pain and prescription opioid abuse. Clinical trials. In general clinical trials have not been a source of systematically collected information about abuse liability. Reasons for this include the lack of validated methods, particularly outcome measures relevant to abuse; lack of validated constructs and diagnostic criteria such as abuse or addiction in a pain patient and the exclusion from clinical trials of high-risk patients, which results in a low "event rate" in the clinical trial setting. Unfortunately, even where validated methods exist, there are rarely applied in a systematic manner. Abuse-related data from clinical trials is currently passively collected e.g. spontaneous reports of putatively abuse-related adverse events, loss of drug supply ; , and interpreted, without any scientific consensus around appropriate methods and interpretation. Despite these limitations, important information on abuse liability can and should be gathered prospectively during the drug development process. Investigators have shown that events potentially related to abuse or diversion can be prospectively collected and adjudicated. The absence of such findings is also highly informative when captured systematically, and has found its way into product labels. Differences in the incidence of aberrant drug behaviors between high- and low-risk patients can be demonstrated in naturalistic studies. The group felt that abuse deterrence of a formulation could be demonstrated in a clinical trial of high-risk patients using a time-to-exit approach, with exit criteria based on evidence of abuse. In addition, methods are emerging to directly assess the "attractiveness" of products to abusers; such methods may have a role in assessing abuse liability in the premarket phase. Epidemiology. Epidemiologic studies are currently viewed as the gold standard for making explicit claims about the extent to which one product is abused compared to another in the community, the sine qua non of abuse resistance. Unfortunately, no such studies have been published, and there is no consensus about accepted methods for conducting or interpreting such studies. Further work is needed to determine the goals, methods, and interpretation of such studies, and their labeling implications. Surveillance may be defined as "the ongoing systematic collection, analysis, and interpretation of outcomespecific data for use in the planning, implementation, and evaluation of public health practice" Centers for Disease Control and Prevention ; . Although there are a plethora of databases and surveillance systems in place for drug abuse, and for prescriptions in general, no surveillance systems exist that provide scientifically valid and.

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